The mechanism of Z alpha 1-antitrypsin accumulation in the liver.
about
Uptake of the necrotic serpin in Drosophila melanogaster via the lipophorin receptor-1Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomesRationale and design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis. Alpha-1 protocolLong chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cellsHuman EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteinsCharacterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: one for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ.X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensationAlpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapyLiver injury in alpha1-antitrypsin deficiency: an aggregated protein induces mitochondrial injurySerpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functionsGenes and chronic obstructive pulmonary diseaseArabidopsis AtSerpin1, crystal structure and in vivo interaction with its target protease RESPONSIVE TO DESICCATION-21 (RD21)α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8Maspin (SERPINB5) is an obligate intracellular serpinThe structural diversity in α1-antitrypsin misfoldingSmall molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregatesLipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in miceMegsin gene: its genomic analysis, pathobiological functions, and therapeutic perspectivesCleaved antitrypsin polymers at atomic resolutionalpha1-Antitrypsin deficiency . 6: new and emerging treatments for alpha1-antitrypsin deficiencyAn overview of the serpin superfamilyThe genetics of chronic obstructive pulmonary diseaseConcentration-dependent effects of native and polymerised alpha1-antitrypsin on primary human monocytes, in vitroAlpha-1 antitrypsin deficiency is not a rare disease but a disease that is rarely diagnosedIs there a therapeutic role for selenium in alpha-1 antitrypsin deficiency?Mechanisms of protein-folding diseases at a glanceHuman pluripotent stem cells for modelling human liver diseases and cell therapyThe delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologyHepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteinsSerpin polymerization is prevented by a hydrogen bond network that is centered on his-334 and stabilized by glycerolPreventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfoldingCrystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α1-Antitrypsin: Implications for Disease and Drug DesignTherapeutic target-site variability in α1-antitrypsin characterized at high resolutionInhibitory conformation of the reactive loop of alpha 1-antitrypsinADD66, a gene involved in the endoplasmic reticulum-associated degradation of alpha-1-antitrypsin-Z in yeast, facilitates proteasome activity and assembly.Familial dementia caused by polymerization of mutant neuroserpinThe molecular interactions of heat shock protein 47 (Hsp47) and their implications for collagen biosynthesisEDEM accelerates ERAD by preventing aberrant dimer formation of misfolded alpha1-antitrypsinNeuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer diseaseMutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulum
P2860
Q21144995-A467F945-8D6B-4112-839D-1E5E0C60E5A7Q21283750-E9248157-C6D9-423C-A03E-1CF81AE39115Q23911017-93746F49-FE46-4D22-82F2-99A8CA49747FQ24300446-6BC67D81-2380-443D-8712-DB96551F4E49Q24313639-5ACBA9BB-5E96-4327-84D8-5FABA6E97D90Q24537406-64DD157B-250A-4220-B52E-CB53961BA007Q24550849-9D078FBA-64D2-4B7A-8E82-32AEDF66D0C1Q24554310-E603F969-A984-4626-A6C2-8183480E8597Q24554312-12B2D61C-8C77-4106-B1DC-C5FCD3482EFBQ24597208-DB83DF82-7116-4CA0-ADC1-FC99A51D5BC2Q24630805-E2A9EC74-8A5B-408E-B35F-EACE94B9C1DDQ24632743-F3A8237F-AB18-41A4-875D-BE0C8846060BQ24633462-D05EB431-5ED7-4C8B-993D-B1CD92F31847Q24634632-E0BF9067-13CE-4BE2-8B53-00606E09DB9AQ24635283-C6128109-B489-45CF-93E9-4EAF14AE6686Q24645055-BBC8862D-03F8-4A1A-BA69-8D80F2E6663CQ24649564-BCB113D6-6638-45B3-85E9-BE733DC1EFCEQ24651558-F8AD0736-CB93-4903-8F6C-8096FFDCE1FFQ24672272-FEFE9B81-8F52-4646-8725-CAB45C7146F4Q24678727-2836643E-29E7-4A4A-80BE-531AC07F0119Q24684030-50C116C8-DC0C-43E3-85A8-3E8A35F1E064Q24791708-54559078-4BC7-4713-8CC2-DB10DCFE56C7Q24795113-A843E3A6-7F17-4C16-BF1C-1E82E285B8BDQ24816929-0B9CBA35-FAB3-41C2-9860-5132757432D5Q26851374-D6A9DABD-3BDF-42D5-8A71-0D2BF23714DBQ27003095-01416A8E-3A5F-435C-B3D4-94323EF5D193Q27005360-D94CF79B-535E-464D-B61A-16C24F6E0638Q27015793-09BADBB0-F2A7-4C1D-B1CE-26740A148C36Q27478188-98686070-387E-4D70-93DE-07DA80026568Q27640477-67A5C9EB-F2F3-4A83-B1FA-DD9A303129EDQ27652055-239684A9-75BA-44CD-B7B8-E998E55A16EFQ27653866-AFBD9498-3E52-42EF-98D3-E53F1176ABF8Q27675947-EA403B1F-CFFD-412E-A0FA-5F64B47D5930Q27733292-E7F812A8-D347-4FA6-A906-1FAA8E9595B3Q27932696-B7900B99-2678-40DA-BEFE-6E062C7DD187Q28145741-129CDAE0-05C7-4E50-81FA-B9B4A3BAE239Q28191029-332B6E68-0316-44F0-BDBC-5C96AF6CE9ACQ28235801-8302C05F-076D-42D5-8311-A440D970185FQ28252760-ACA4FCF5-C6E3-4D7A-8A83-AC66B99352DAQ28257006-DC19ECB9-D11A-4A4B-81DE-0E2CFC9B2659
P2860
The mechanism of Z alpha 1-antitrypsin accumulation in the liver.
description
1992 nî lūn-bûn
@nan
1992 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
The mechanism of Z alpha 1-antitrypsin accumulation in the liver.
@ast
The mechanism of Z alpha 1-antitrypsin accumulation in the liver.
@en
The mechanism of Z alpha 1-antitrypsin accumulation in the liver.
@nl
type
label
The mechanism of Z alpha 1-antitrypsin accumulation in the liver.
@ast
The mechanism of Z alpha 1-antitrypsin accumulation in the liver.
@en
The mechanism of Z alpha 1-antitrypsin accumulation in the liver.
@nl
prefLabel
The mechanism of Z alpha 1-antitrypsin accumulation in the liver.
@ast
The mechanism of Z alpha 1-antitrypsin accumulation in the liver.
@en
The mechanism of Z alpha 1-antitrypsin accumulation in the liver.
@nl
P2093
P356
P1433
P1476
The mechanism of Z alpha 1-antitrypsin accumulation in the liver.
@en
P2093
P2888
P304
P356
10.1038/357605A0
P407
P577
1992-06-01T00:00:00Z
P6179
1048738506