Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication. - Wikidata - wikimedia - TriplyDB

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.

http://www.wikidata.org/entity/Q34443810

about

Chutes and ladders in hepatitis C nucleoside drug development Changing the face of hepatitis C management - the design and development of sofosbuvir Mechanism of Activation of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479 Synthesis and Anti-Hepatitis B Virus and Anti-Hepatitis C Virus Activities of 7-Deazaneplanocin A Analogues in Vitro Combinations of 2'-C-methylcytidine analogues with interferon-alpha2b and triple combination with ribavirin in the hepatitis C virus replicon system Efficiency of incorporation and chain termination determines the inhibition potency of 2'-modified nucleotide analogs against hepatitis C virus polymerase Efficacy of 2'-C-methylcytidine against yellow fever virus in cell culture and in a hamster model.Tricyclic 2'-C-modified nucleosides as potential anti-HCV therapeutics.One-electron oxidation of gemcitabine and analogs: mechanism of formation of C3' and C2' sugar radicals.Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species.Pharmacokinetics of the antiviral agent beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine in rhesus monkeys.Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains.Synthesis of DNA oligos containing 2'-deoxy-2'-fluoro-D-arabinofuranosyl-5-carboxylcytosine as hTDG inhibitor.Fluorinated Nucleosides: Synthesis and Biological Implication Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2'-deoxy nucleoside analogues.Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection.Discovery of novel ribonucleoside analogs with activity against human immunodeficiency virus type 1 HCV drug discovery aimed at viral eradication.Nucleoside analog inhibitors of hepatitis C viral replication: recent advances, challenges and trends.Highlights in antiviral drug research: antivirals at the horizon.Synthesis and Anti-HCV Activity of a Novel 2',3'-Dideoxy-2'-α-fluoro-2'-β-C-methyl Guanosine Phosphoramidate Prodrug.Synthesis of novel 4'α-trifluoromethyl-2'β-C-methyl-carbodine analogs as anti-hepatitis C virus agents.Process Chemistry in Antiviral Research.Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.A 2'-deoxy-2'-fluoro-2'-C-methyl uridine cyclopentyl carbocyclic analog and its phosphoramidate prodrug as inhibitors of HCV NS5B polymerase.Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.Design and synthesis of novel carbocyclic versions of 2'-spirocyclopropyl ribonucleosides as potent anti-HCV agents.Synthesis of 2'-fluoro and 2',4'-dimethyl pyrimidine C-nucleoside analogues as potential anti-HCV agents.Synthesis and anti-HCV evaluation of 4'(alpha)-ethyl and 2'(beta)-methyl-carbodine analogues.Synthesis and in vitro activity evaluation of 2',3'-C-dimethyl carbocyclic nucleoside analogues as potential anti-HCV agents.Synthesis and antiviral evaluation of 2'-C-methyl analogues of 5-alkynyl- and 6-alkylfurano- and pyrrolo[2,3-d]pyrimidine ribonucleosides.Regioselective metalation of 6-methylpurines: synthesis of fluoromethyl purines and related nucleosides for suicide gene therapy of cancer.Synthesis and antiviral activity of purine 2',3'-dideoxy-2',3'-difluoro-D-arabinofuranosyl nucleosides.Synthesis and anti-hepatitis C virus activity of 2'(beta)-hydroxyethyl and 4'(alpha)-hydroxymethyl carbodine analogues.Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection Design, synthesis, and antiviral evaluation of some 3'-carboxymethyl-3'-deoxyadenosine derivatives.Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.Discovery of 2'-α-C-Methyl-2'-β-C-fluorouridine Phosphoramidate Prodrugs as Inhibitors of Hepatitis C Virus.

P2860

Q26998630-7D994830-D515-4613-B37A-F6E3DCE3261B Q27011203-D208E04D-1687-4CCC-A268-71CF9C9B2EA9 Q27478073-C7A74987-6821-4FB5-8F98-80CB532A99A6 Q27487389-1F371097-BDE0-48E8-AC5C-B24C146F639B Q27489125-CC8276D5-0C5B-4044-BE0A-88CE0EA6ACCC Q27489596-37B8C318-B0F5-47C8-B8E8-7AFB210D50BF Q33798503-11BC8B50-8277-43BF-B0EB-BC8F8C19E0C2 Q33856419-499E4116-38A9-4CA4-BCBD-B5D339A573C4 Q34286776-6A97E9D4-2DD8-44D5-89B0-F791C4A86688 Q34489433-EC31F98D-7CFD-4E18-A90A-A5CA8C80E3C3 Q34663202-C2A90A8C-883C-47AC-AA00-323017660157 Q35912736-1E63F1DE-F486-49CB-BCFF-557D72D50E5F Q35935502-F46A2375-295F-4FD2-B633-555240984405 Q36034586-163DD1CF-97A2-495E-A573-D219EFAB8BF4 Q36974059-40024BC1-22D8-48FE-9F3E-D80FA1007FB0 Q37054804-5C6DF1F1-755C-4E72-B479-0FC0FB3588AB Q37481292-25A23ACE-1C2A-4684-96B8-C99942530B78 Q37547746-99904AA6-5CF4-4373-A963-B3F3A4001B30 Q37664059-A7EB3CDC-BEEF-4D22-B585-7693E0D64F40 Q37855863-897E3E77-1FC0-4ABB-B18A-D548827513FD Q38007145-277256A7-01AA-40BA-985B-7443D21CB900 Q38699932-5A00793D-3C24-41F8-B5CE-54B5F2F5F7F6 Q38916474-E293495F-72E1-4D54-8B66-05A21D0AC23A Q38997200-79A42974-8E1D-4C01-9EC5-518D1995FB47 Q39159639-194B060B-99B4-42D9-BA25-21EAF2072B3C Q39374800-B2BBADC6-A663-465B-9562-64C1629D0454 Q39455374-20B2F055-AE9D-44DB-8ADC-B2F4FB784204 Q39461131-8AFE3600-ACB4-4341-99AC-7CA0488A6A72 Q39502501-E1E90FE2-BAB3-4BD4-8059-FCA6865B0ECA Q39712455-1C8D23DC-2F8B-463E-829C-B7FBED5B0CA3 Q39735236-DDAB76E6-17BA-481F-B386-35DF8E877059 Q39735241-D593FAF6-4D43-4D51-8DA5-6D3F24771999 Q39735250-D1D9DB7F-E1E8-4490-A198-2E4E146A9026 Q39735268-243D43C3-B0C9-4FE7-A8F5-A173C0C7C810 Q39735281-0DE7A8C0-6906-430B-8626-B6AA01963F6B Q39735308-FAF90AA0-27D7-43CE-921E-64C56C0C1AD4 Q39792685-EE826799-D8B4-4C52-9D8B-24CC98B98B28 Q40117943-C9963341-DBF9-46EF-B378-CB13B341F5BA Q40220112-8990F4F3-397F-4838-8823-716FBD9646AE Q40416944-5F855D24-2F3B-46F6-9187-1032B568EE4C

P2860

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.

http://www.wikidata.org/entity/Q34443810

description

2005 nî lūn-bûn

@nan

2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年学术文章

@wuu

2005年学术文章

@zh-cn

2005年学术文章

@zh-hans

2005年学术文章

@zh-my

2005年学术文章

@zh-sg

2005年學術文章

@yue

name

Design, synthesis, and antivir ...... hepatitis C virus replication.

@ast

Design, synthesis, and antivir ...... hepatitis C virus replication.

@en

Design, synthesis, and antivir ...... hepatitis C virus replication.

@nl

type

label

Design, synthesis, and antivir ...... hepatitis C virus replication.

@ast

Design, synthesis, and antivir ...... hepatitis C virus replication.

@en

Design, synthesis, and antivir ...... hepatitis C virus replication.

@nl

prefLabel

Design, synthesis, and antivir ...... hepatitis C virus replication.

@ast

Design, synthesis, and antivir ...... hepatitis C virus replication.

@en

Design, synthesis, and antivir ...... hepatitis C virus replication.

@nl

P1433

Q34443810-FED6E7FB-7839-437B-BCB4-D980836E94D3

P1476

Q34443810-D2F40D47-4B35-4591-AD7C-9C2D2CEE9534

P2093

Q34443810-015D9093-F7D9-4EAD-B7DB-E85DA63801E7

Q34443810-18D384BC-2D08-44C0-9289-F536B798FBC6

Q34443810-20C7BA77-C7A3-480D-9874-9973B5E17D24

Q34443810-41AE3613-27D0-4CF6-AF34-6B660CBA8E0F

Q34443810-4411CA6C-C02B-47BB-B804-FE1003733FFE

Q34443810-4BD7C371-57DB-4A5F-8EA4-15CB01D2607F

Q34443810-9DD19944-9696-460B-991D-6B32017418CC

Q34443810-ADD6C7D2-D954-4562-88BF-62B18FC93B5F

Q34443810-B2048895-2F8B-4F08-8DD5-F9E5C56ABD00

Q34443810-D8656392-2305-463E-B866-6267A1DBC33D

P304

Q34443810-DBCA1992-D1D4-42E9-9B29-BFD0031BAC5B

P31

Q34443810-7C2F8B5D-135E-4627-8CA1-C85A7E25ADB8

P356

Q34443810-D0A47C4D-C958-4A64-9640-AFAA72F4BA9E

P407

Q34443810-255E84DC-C64E-4940-97D3-C5913D97E68C

P433

Q34443810-FB53B444-9391-4819-AE63-04FB123FCC34

P478

Q34443810-2BF4AAB8-8C6B-48BB-9138-253975692159

P50

Q34443810-D38561EA-0290-4E8B-8566-C4731CACC0B0

P577

Q34443810-9263E6A8-95DA-4D46-9044-7E2B298ADF2E

P698

Q34443810-4714DFFC-F107-4AB5-A95C-124907649D6F

P356

P1433

Journal of Medicinal Chemistry

P1476

Design, synthesis, and antivir ...... hepatitis C virus replication.

@en

P2093

J Christian Mason

http://www.w3.org/2001/XMLSchema#string

Jeremy L Clark

http://www.w3.org/2001/XMLSchema#string

Krzysztof W Pankiewicz

http://www.w3.org/2001/XMLSchema#string

Kyoichi A Watanabe

http://www.w3.org/2001/XMLSchema#string

Laurent Hollecker

http://www.w3.org/2001/XMLSchema#string

Lieven J Stuyver

http://www.w3.org/2001/XMLSchema#string

Michael J Otto

http://www.w3.org/2001/XMLSchema#string

Phillip A Furman

http://www.w3.org/2001/XMLSchema#string

Phillip M Tharnish

http://www.w3.org/2001/XMLSchema#string

Stefania Lostia

http://www.w3.org/2001/XMLSchema#string

P304

5504-5508

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1021/JM0502788

http://www.w3.org/2001/XMLSchema#string

P407

P433

17

http://www.w3.org/2001/XMLSchema#string

P478

48

http://www.w3.org/2001/XMLSchema#string

P50

Raymond F. Schinazi

P577

2005-08-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

16107149

http://www.w3.org/2001/XMLSchema#string