Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease.
about
Lamin A/C haploinsufficiency modulates the differentiation potential of mouse embryonic stem cellsCardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- miceCardiac disease and arrhythmogenesis: Mechanistic insights from mouse modelsGenetic Variations Leading to Familial Dilated CardiomyopathyRecent advances in animal and human pluripotent stem cell modeling of cardiac laminopathyThe cardiac conduction systemLaminopathies and the long strange trip from basic cell biology to therapyLMNA E82K mutation activates FAS and mitochondrial pathways of apoptosis in heart tissue specific transgenic miceDiseases of the nuclear envelope.Uncoordinated transcription and compromised muscle function in the lmna-null mouse model of Emery- Emery-Dreyfuss muscular dystrophy.Attenuated hypertrophic response to pressure overload in a lamin A/C haploinsufficiency mouseDeletion of the lmna gene induces growth delay and serum biochemical changes in C57BL/6 miceDirect synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice.RNAi-based gene therapy for dominant Limb Girdle Muscular Dystrophies.Differential temporal and spatial progerin expression during closure of the ductus arteriosus in neonatesCardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β.LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins.Cellular mechanosensing: getting to the nucleus of it all.Investigating the purpose of prelamin A processingPost-natal myogenic and adipogenic developmental: defects and metabolic impairment upon loss of A-type lamins.Energetics, epigenetics, mitochondrial genetics.Nuclear lamins: key regulators of nuclear structure and activitiesSustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fatesExome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy.Modeling of lamin A/C mutation premature cardiac aging using patient‐specific induced pluripotent stem cells.Targeting Mitogen-Activated Protein Kinase Signaling in Mouse Models of Cardiomyopathy Caused by Lamin A/C Gene MutationsDeleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy.Nuclear shape, mechanics, and mechanotransduction.Generation and characterization of a conditional deletion allele for Lmna in mice.Defective skeletal muscle growth in lamin A/C-deficient mice is rescued by loss of Lap2α.Molecular mechanisms of inherited arrhythmias.Genetic and ultrastructural studies in dilated cardiomyopathy patients: a large deletion in the lamin A/C gene is associated with cardiomyocyte nuclear envelope disruption.Animal models of arrhythmogenic cardiomyopathy.Role of nuclear Lamin A/C in cardiomyocyte functions.What Should the Cardiologist know about Lamin Disease?Murine Electrophysiological Models of Cardiac Arrhythmogenesis.Current insights into LMNA cardiomyopathies: Existing models and missing LINCsA truncated lamin A in the Lmna -/- mouse line: implications for the understanding of laminopathies.Nesprin-1 mutations in human and murine cardiomyopathy.Modeling Treatment Response for Lamin A/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells.
P2860
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P2860
Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease.
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Lamin A/C haploinsufficiency c ...... iac conduction system disease.
@ast
Lamin A/C haploinsufficiency c ...... iac conduction system disease.
@en
Lamin A/C haploinsufficiency c ...... iac conduction system disease.
@nl
type
label
Lamin A/C haploinsufficiency c ...... iac conduction system disease.
@ast
Lamin A/C haploinsufficiency c ...... iac conduction system disease.
@en
Lamin A/C haploinsufficiency c ...... iac conduction system disease.
@nl
prefLabel
Lamin A/C haploinsufficiency c ...... iac conduction system disease.
@ast
Lamin A/C haploinsufficiency c ...... iac conduction system disease.
@en
Lamin A/C haploinsufficiency c ...... iac conduction system disease.
@nl
P2093
P2860
P50
P1476
Lamin A/C haploinsufficiency c ...... diac conduction system disease
@en
P2093
Charles I Berul
Christine E Seidman
Colin L Stewart
Cordula M Wolf
David A Conner
Dorothy M Branco
Hiroko Wakimoto
J G Seidman
Libin Wang
Megan Sherwood
P2860
P304
P356
10.1016/J.YJMCC.2007.11.008
P577
2007-12-03T00:00:00Z