Rapid accumulation of genome rearrangements in liver but not in brain of old mice.
about
Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with ageDelayed and accelerated aging share common longevity assurance mechanismsDisruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation.Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic miceDeletion of Ku70, Ku80, or both causes early aging without substantially increased cancerDeletion of Ku86 causes early onset of senescence in miceChallenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutationsGrowth conditions that increase or decrease lifespan in Saccharomyces cerevisiae lead to corresponding decreases or increases in rates of interstitial deletions and non-reciprocal translocationsIntra-organ variation in age-related mutation accumulation in the mouse.Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cellsKu80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response.Molecular and phenotypic biomarkers of agingSomatic mutations, genome mosaicism, cancer and aging.Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging.Mutational fingerprints of aging.Genetic instability favoring transversions associated with ErbB2-induced mammary tumorigenesis.DNA repair in species with extreme lifespan differences.Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging.Cellular stress response pathways and ageing: intricate molecular relationshipsBroad segmental progeroid changes in short-lived Ercc1(-/Δ7) miceAging genomes: a necessary evil in the logic of life.Tissue-specific differences in the accumulation of sequence rearrangements with age.Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing.Age-related somatic mutations in the cancer genomeImpaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans.Telomeres, aging and cancer: in search of a happy ending.Do DNA Double-Strand Breaks Drive Aging?Accurate quantification of more than 4000 mouse tissue proteins reveals minimal proteome changes during aging.Changes in DNA repair during aging.Metabolism, genomics, and DNA repair in the mouse aging liver.Slow accumulation of mutations in Xpc-/- mice upon induction of oxidative stress.Oxidative stress, cell cycle, and neurodegeneration.Genome dynamics and transcriptional deregulation in aging.Attenuation of DNA polymerase beta-dependent base excision repair and increased DMS-induced mutagenicity in aged mice.Stem cells from birth to death: The history and the futureStem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs.Mutational load distribution analysis yields metrics reflecting genetic instability during pancreatic carcinogenesis.Resistance to genotoxic stresses in Arctica islandica, the longest living noncolonial animal: is extreme longevity associated with a multistress resistance phenotype?DNA damage in normally and prematurely aged mice.
P2860
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P2860
Rapid accumulation of genome rearrangements in liver but not in brain of old mice.
description
1997 nî lūn-bûn
@nan
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Rapid accumulation of genome rearrangements in liver but not in brain of old mice.
@ast
Rapid accumulation of genome rearrangements in liver but not in brain of old mice.
@en
Rapid accumulation of genome rearrangements in liver but not in brain of old mice.
@nl
type
label
Rapid accumulation of genome rearrangements in liver but not in brain of old mice.
@ast
Rapid accumulation of genome rearrangements in liver but not in brain of old mice.
@en
Rapid accumulation of genome rearrangements in liver but not in brain of old mice.
@nl
prefLabel
Rapid accumulation of genome rearrangements in liver but not in brain of old mice.
@ast
Rapid accumulation of genome rearrangements in liver but not in brain of old mice.
@en
Rapid accumulation of genome rearrangements in liver but not in brain of old mice.
@nl
P2093
P356
P1433
P1476
Rapid accumulation of genome rearrangements in liver but not in brain of old mice.
@en
P2093
P2888
P304
P356
10.1038/NG1297-431
P407
P577
1997-12-01T00:00:00Z