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The Unspecific Side of Acquired Immunity Against Infectious Disease: Causes and ConsequencesTLR cross-talk confers specificity to innate immunityEpitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complexBiochemical and Structural Characterization of Lysophosphatidic Acid Binding by a Humanized Monoclonal AntibodyThe effect of mutations on the alloreactive T cell receptor/peptide-MHC interface structure: a molecular dynamics study.A cryptic polyreactive antibody recognizes distinct clades of HIV-1 glycoprotein 120 by an identical binding mechanism"Rational vaccine design" for HIV should take into account the adaptive potential of polyreactive antibodies.Identification and characterization of a multispecific monoclonal antibody G2 against chicken prion proteinThe anti-cancer IgM monoclonal antibody PAT-SM6 binds with high avidity to the unfolded protein response regulator GRP78.Intramolecular polyspecificity in CD4 T-cell recognition of Ad-restricted epitopes of proteoglycan aggrecan.Antibody engineering for increased potency, breadth and half-life.Evaluation of pneumonia virus of mice as a possible human pathogenAntigen-driven induction of polyreactive IgM during intracellular bacterial infection.Tuning the specificity of a Two-in-One Fab against three angiogenic antigens by fully utilizing the information of deep mutational scanning.Impact of Obesity and Metabolic Syndrome on Immunity.Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits.Immunopaleontology reveals how affinity enhancement is achieved during affinity maturation of antibodies to influenza virusViral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection.Cross-reactivity of T cells and its role in the immune systemPolyreactive antibodies in adaptive immune responses to viruses.Basic research in HIV vaccinology is hampered by reductionist thinking.Engineering approaches to immunotherapy.Specificity, polyspecificity, and heterospecificity of antibody-antigen recognition.An Outdated Notion of Antibody Specificity is One of the Major Detrimental Assumptions of the Structure-Based Reverse Vaccinology Paradigm, Which Prevented It from Helping to Develop an Effective HIV-1 Vaccine.How to assess the binding strength of antibodies elicited by vaccination against HIV and other viruses.Increased exposure to Plasmodium chabaudi antigens sustains cross-reactivity and avidity of antibodies binding Nippostrongylus brasiliensis: dissecting cross-phylum cross-reactivity in a rodent model.Spot peptide arrays and SPR measurements: throughput and quantification in antibody selectivity studies.Rigidity Emerges during Antibody Evolution in Three Distinct Antibody Systems: Evidence from QSFR Analysis of Fab Fragments.Editorial: Paradigm Changes are Required in HIV Vaccine Research.Development of a Preventive HIV Vaccine Requires Solving Inverse Problems Which Is Unattainable by Rational Vaccine Design.A multispecific monoclonal antibody G2 recognizes at least three completely different epitope sequences with high affinity.Development of quantitative suspension array assays for six immunoglobulin isotypes and subclasses to multiple Plasmodium falciparum antigens.Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies.Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis.Why Does the Molecular Structure of Broadly Neutralizing Monoclonal Antibodies Isolated from Individuals Infected with HIV-1 not Inform the Rational Design of an HIV-1 Vaccine?Optimization of incubation conditions of Plasmodium falciparum antibody multiplex assays to measure IgG, IgG1-4, IgM and IgE using standard and customized reference pools for sero-epidemiological and vaccine studies.Repertoire Analysis of Antibody CDR-H3 Loops Suggests Affinity Maturation Does Not Typically Result in Rigidification.The Influence of T Cell Development on Pathogen Specificity and Autoreactivity
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Evolving concepts of specificity in immune reactions
@ast
Evolving concepts of specificity in immune reactions
@en
Evolving concepts of specificity in immune reactions
@nl
type
label
Evolving concepts of specificity in immune reactions
@ast
Evolving concepts of specificity in immune reactions
@en
Evolving concepts of specificity in immune reactions
@nl
prefLabel
Evolving concepts of specificity in immune reactions
@ast
Evolving concepts of specificity in immune reactions
@en
Evolving concepts of specificity in immune reactions
@nl
P2860
P356
P1476
Evolving concepts of specificity in immune reactions
@en
P2093
Arup K Chakraborty
Herman N Eisen
P2860
P304
22373-22380
P356
10.1073/PNAS.1012051108
P407
P577
2010-12-20T00:00:00Z