LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria. - Wikidata - wikimedia - TriplyDB

LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria.

LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria.

http://www.wikidata.org/entity/Q34453596

about

A review of ceramide analogs as potential anticancer agents Ceramide induced mitophagy and tumor suppression On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging.Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death.Tissue biomarkers of drug efficacy: case studies using a MALDI-MSI workflow.Treatment of a chemoresistant neuroblastoma cell line with the antimalarial ozonide OZ513.Therapeutic Targeting of the Mitochondria Initiates Excessive Superoxide Production and Mitochondrial Depolarization Causing Decreased mtDNA Integrity Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells Cationic ceramides and analogues, LCL30 and LCL85, as adjuvants to photodynamic therapy of tumors.Sphingolipids and mitochondrial apoptosis.3-Ketone-4,6-diene ceramide analogs exclusively induce apoptosis in chemo-resistant cancer cells.Major apoptotic mechanisms and genes involved in apoptosis.Delivery systems of ceramide in targeted cancer therapy: ceramide alone or in combination with other anti-tumor agents.Targeting reactive oxygen species in development and progression of pancreatic cancer.Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications.Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML.MitoQ regulates autophagy by inducing a pseudo-mitochondrial membrane potential.Sphingolipid metabolism in cancer signalling and therapy.Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq

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P2860

LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria.

http://www.wikidata.org/entity/Q34453596

description

2012 nî lūn-bûn

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2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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name

LCL124, a cationic analog of c ...... accumulating in mitochondria.

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LCL124, a cationic analog of c ...... accumulating in mitochondria.

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LCL124, a cationic analog of c ...... accumulating in mitochondria.

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LCL124, a cationic analog of c ...... accumulating in mitochondria.

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LCL124, a cationic analog of c ...... accumulating in mitochondria.

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LCL124, a cationic analog of c ...... accumulating in mitochondria.

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JPET.112.199216

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Journal of Pharmacology and Experimental Therapeutics

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LCL124, a cationic analog of c ...... accumulating in mitochondria.

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P2093

Alicja Bielawska

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Besim Ogretmen

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Clayton S Lewis

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Craig C Beeson

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Elizabeth E Jones

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Gyda Beeson

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Jacek Bielawski

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James S Norris

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Joseph C Cheng

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Ping Lu

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P2860

Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

Fine mapping the spatial distribution and concentration of unlabeled drugs within tissue micro-compartments using imaging mass spectrometry.

Chemiosmotic hypothesis of oxidative phosphorylation

Mitochondrial Membrane Potential in Living Cells

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial

FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

Tailoring structure-function and targeting properties of ceramides by site-specific cationization.

MALDI-FTICR imaging mass spectrometry of drugs and metabolites in tissue.

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167-178

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scholarly article

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10.1124/JPET.112.199216

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