A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo.
about
Antitumor Activity of 2,9-Di-Sec-Butyl-1,10-PhenanthrolineCopper(ii) thiosemicarbazone complexes induce marked ROS accumulation and promote nrf2-mediated antioxidant response in highly resistant breast cancer cells.The copper radioisotopes: a systematic review with special interest to 64Cu.Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity.Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes.A selenosemicarbazone complex with copper efficiently down-regulates the 90-kDa heat shock protein HSP90AA1 and its client proteins in cancer cells.Characterization of the anticancer effects of S115, a novel heteroaromatic thiosemicarbazone compound, in vitro and in vivo.Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cellsVisualization of copper metabolism by 64CuCl₂-PET.Doubly chloro bridged dimeric copper(II) complex: magneto-structural correlation and anticancer activity.Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytesCHOP and caspase 3 induction underlie glioblastoma cell death in response to endoplasmic reticulum stress.Iron-targeting antitumor activity of gallium compounds and novel insights into triapine(®)-metal complexes.Catalytic nanomedicine technology: copper complexes loaded on titania nanomaterials as cytotoxic agents of cancer cell.Nickel chloride (NiCl2) induces endoplasmic reticulum (ER) stress by activating UPR pathways in the kidney of broiler chickensPerspective: Opportunities in recalcitrant, rare and neglected tumors.Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis.Anticancer activity of metal complexes: involvement of redox processes.Copper complexes as therapeutic agents.Design and optimization of drugs used to treat copper deficiency.Metallomics insights into the programmed cell death induced by metal-based anticancer compounds.Copper and its complexes in medicine: a biochemical approach.Increased generation of intracellular reactive oxygen species initiates selective cytotoxicity against the MCF-7 cell line resultant from redox active combination therapy using copper-thiosemicarbazone complexes.A ratiometric fluorescent sensor for the mitochondrial copper pool.Organelle-selective fluorescent Cu2+ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading.
P2860
Q28468510-870AACD0-A4C0-4FA4-986A-D72C19A5CD0EQ31172464-19F32618-0CF3-4152-ACA7-0DA47740741CQ33661508-E80BC2A9-10F4-4650-AFA7-CC57B4C93836Q33728282-ACBEC077-0A26-4ACF-8A23-FC73718E6FDCQ34178561-482777EB-B945-4FD9-95F9-3E44D837E696Q34208541-065F161E-181C-4D0C-A9E0-22E5F4C3A073Q34295036-CCFE5196-4AE0-44B0-ADC2-97F70A09D32EQ34373124-0A3577B8-C0B7-4731-8807-5212DD5ED1D8Q35161173-B83BB550-DAF0-4849-9468-BAEB31D35705Q35600808-4A54CFC7-6612-4E87-A64A-63453F411D0BQ35823218-6B067951-DA7A-4297-8773-A4E14825FE67Q36224311-96B2CF40-CF9A-4DC2-A581-E17BADB73D58Q36568904-3B231BD4-287D-4BFE-8171-829E2564281AQ36611057-11D51B46-9AF6-4134-A485-B5CAA963EA27Q37109518-5374EB99-8013-4DE6-85F8-E0F2AF20D08AQ37197528-748BD5CE-49FF-4035-A56A-128F465ABFF5Q37482581-2A9BDAB0-02AE-43AA-A075-D62FA43686F0Q37833099-1F899918-BBAE-45EC-B446-C8E721B6D8D6Q37970312-BF462D72-63A3-4C7F-993A-459E8C6718E0Q38126969-78EF340C-4148-461C-8E27-07F9D1F41796Q38199383-B4A1FDE2-E691-4FE5-BD68-C248B7C64A27Q38730238-BB047587-CCDE-4C60-AD9E-FE4E70A3F1BBQ38788219-2D97213C-C9E3-407E-8FDD-AD3CE723E5ADQ50197759-72AD876B-1495-4B6C-B551-857AD3BF9071Q53295918-E7AB1BF9-BECF-4405-AD50-6CBF17227464
P2860
A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A copper chelate of thiosemica ...... r growth in vitro and in vivo.
@ast
A copper chelate of thiosemica ...... r growth in vitro and in vivo.
@en
A copper chelate of thiosemica ...... r growth in vitro and in vivo.
@nl
type
label
A copper chelate of thiosemica ...... r growth in vitro and in vivo.
@ast
A copper chelate of thiosemica ...... r growth in vitro and in vivo.
@en
A copper chelate of thiosemica ...... r growth in vitro and in vivo.
@nl
prefLabel
A copper chelate of thiosemica ...... r growth in vitro and in vivo.
@ast
A copper chelate of thiosemica ...... r growth in vitro and in vivo.
@en
A copper chelate of thiosemica ...... r growth in vitro and in vivo.
@nl
P2093
P2860
P1476
A copper chelate of thiosemica ...... r growth in vitro and in vivo.
@en
P2093
Bingnan Han
Chad N Hancock
Dianne L Newton
Jung Ho Jun
Luke H Stockwin
Melinda G Hollingshead
Raymond D Divelbiss
Sanjay V Malhotra
P2860
P304
P356
10.1016/J.FREERADBIOMED.2010.10.696
P577
2010-11-04T00:00:00Z