The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors. - Wikidata - wikimedia - TriplyDB

The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.

The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.

http://www.wikidata.org/entity/Q34459061

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Polycomb repressive complex's evolutionary conserved function: the role of EZH2 status and cellular background Targeting EZH2 in cancer Histone Modifications, Modifiers and Readers in Melanoma Resistance to Targeted and Immune Therapy Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes EZH2 as a mediator of treatment resistance in melanoma Epigenetic determinants of metastasis Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases Estrogens in Male Physiology Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia.Indicators of responsiveness to immune checkpoint inhibitors EZH2-mediated epigenetic silencing of TIMP2 promotes ovarian cancer migration and invasion.NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF.Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target.Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma Targeted next-generation sequencing reveals high frequency of mutations in epigenetic regulators across treatment-naïve patient melanomas.Aberrant expression of ALK and EZH2 in Merkel cell carcinoma Nifuroxazide exerts potent anti-tumor and anti-metastasis activity in melanoma Targeting EZH2 regulates tumor growth and apoptosis through modulating mitochondria dependent cell-death pathway in HNSCC.Mutual regulation between CHD5 and EZH2 in hepatocellular carcinoma.Inhibition of EZH2 by chemo- and radiotherapy agents and small molecule inhibitors induces cell death in castration-resistant prostate cancer Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation-induced MPNST.Role of EZH2 histone methyltrasferase in melanoma progression and metastasis Somatic Copy Number Amplification and Hyperactivating Somatic Mutations of EZH2 Correlate With DNA Methylation and Drive Epigenetic Silencing of Genes Involved in Tumor Suppression and Immune Responses in Melanoma Thin and thick primary cutaneous melanomas reveal distinct patterns of somatic copy number alterations.Future perspectives in melanoma research : Meeting report from the "Melanoma Bridge". Napoli, December 1st-4th 2015.LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2.Integrated bioinformatics analysis of chromatin regulator EZH2 in regulating mRNA and lncRNA expression by ChIP sequencing and RNA sequencing.Context-dependent actions of Polycomb repressors in cancer.Transcription factors that interact with p53 and Mdm2 Inhibitors of emerging epigenetic targets for cancer therapy: a patent review (2010-2014).Mutation spectra of histone methyltransferases with canonical SET domains and EZH2-targeted therapy.EZH2-mediated upregulation of ROS1 oncogene promotes oral cancer metastasis.Histone variants and melanoma: facts and hypotheses.Mutations and deletions of PRC2 in prostate cancer.Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer.H3K27 Methylation: A Focal Point of Epigenetic Deregulation in Cancer.Dysregulation of histone methyltransferases in breast cancer - Opportunities for new targeted therapies?Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2.Structure of the PRC2 complex and application to drug discovery.

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The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.

http://www.wikidata.org/entity/Q34459061

description

2015 nî lūn-bûn

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2015 թուականի Յունուարին հրատարակուած գիտական յօդուած

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The epigenetic modifier EZH2 c ...... f distinct tumour suppressors.

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The epigenetic modifier EZH2 c ...... f distinct tumour suppressors.

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The epigenetic modifier EZH2 c ...... f distinct tumour suppressors.

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The epigenetic modifier EZH2 c ...... f distinct tumour suppressors.

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The epigenetic modifier EZH2 c ...... f distinct tumour suppressors.

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The epigenetic modifier EZH2 c ...... f distinct tumour suppressors.

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The epigenetic modifier EZH2 c ...... f distinct tumour suppressors.

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The epigenetic modifier EZH2 c ...... f distinct tumour suppressors.

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The epigenetic modifier EZH2 c ...... f distinct tumour suppressors.

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Nature Communications

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The epigenetic modifier EZH2 c ...... of distinct tumour suppressors

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Caretha L Creasy

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Eylul Tuncer

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Jessica Haeusel

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Julien Debbache

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Mario Bonalli

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Michael T McCabe

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Mitchell P Levesque

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Olga Shakhova

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Raffaella Santoro

http://www.w3.org/2001/XMLSchema#string

Reinhard Dummer

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Molecular architecture of human polycomb repressive complex 2

An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB

A landscape of driver mutations in melanoma

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

A dual role for SOX10 in the maintenance of the postnatal melanocyte lineage and the differentiation of melanocyte stem cell progenitors

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

Generalized lacZ expression with the ROSA26 Cre reporter strain

Cancer statistics, 2014

A perspective on cancer cell metastasis

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10.1038/NCOMMS7051

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6

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Natalia Arenas-Ramirez

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2015-01-22T00:00:00Z

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271216998

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