MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells.
about
MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbodyTat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signalingRho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cellsThe SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein UnkemptHuman mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphasePhosphoregulation of MgcRacGAP in mitosis involves Aurora B and Cdk1 protein kinases and the PP2A phosphataseAn ECT2-centralspindlin complex regulates the localization and function of RhoASequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis.Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosisThe 3Ms of central spindle assembly: microtubules, motors and MAPsCYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesisCentralspindlin: at the heart of cytokinesisTum/RacGAP functions as a switch activating the Pav/kinesin-6 motor.APC(CDH1) targets MgcRacGAP for destruction in the late M phaseCdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.Rho GTPase activity zones and transient contractile arraysStructure and expression of murine mgcRacGAP: its developmental regulation suggests a role for the Rac/MgcRacGAP signalling pathway in neurogenesisIdentification and characterization of a novel Rab GTPase-activating protein in spermatidsRac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway.Role of a novel coiled-coil domain-containing protein CCDC69 in regulating central spindle assembly.Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS.Cooperative assembly of CYK-4/MgcRacGAP and ZEN-4/MKLP1 to form the centralspindlin complex.Implantation of the human embryo requires Rac1-dependent endometrial stromal cell migrationCYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesisA conserved RhoGAP limits M phase contractility and coordinates with microtubule asters to confine RhoA during cytokinesisDiscovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP.MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell-cell junctions in epithelial cells.The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse.Polarity proteins and cell-cell interactions in the testis.CYK-4 regulates Rac, but not Rho, during cytokinesis.MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assemblyFunction and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis.Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells.Identification of a mitotic Rac-GEF, Trio, that counteracts MgcRacGAP function during cytokinesisThe R(h)oads to Stat3: Stat3 activation by the Rho GTPases.Germ cell intercellular bridgesCytokinesis in animal cellsThe RhoGAP domain of CYK-4 has an essential role in RhoA activation.The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis.Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac
P2860
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P2860
MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells.
description
1998 nî lūn-bûn
@nan
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
MgcRacGAP, a new human GTPase- ...... expressed in male germ cells.
@ast
MgcRacGAP, a new human GTPase- ...... expressed in male germ cells.
@en
MgcRacGAP, a new human GTPase- ...... expressed in male germ cells.
@nl
type
label
MgcRacGAP, a new human GTPase- ...... expressed in male germ cells.
@ast
MgcRacGAP, a new human GTPase- ...... expressed in male germ cells.
@en
MgcRacGAP, a new human GTPase- ...... expressed in male germ cells.
@nl
prefLabel
MgcRacGAP, a new human GTPase- ...... expressed in male germ cells.
@ast
MgcRacGAP, a new human GTPase- ...... expressed in male germ cells.
@en
MgcRacGAP, a new human GTPase- ...... expressed in male germ cells.
@nl
P2093
P2860
P356
P1476
MgcRacGAP, a new human GTPase- ...... expressed in male germ cells.
@en
P2093
Dorseuil O
P2860
P304
P356
10.1074/JBC.273.11.6019
P407
P577
1998-03-01T00:00:00Z