Isolation and crystallization of functionally competent Escherichia coli peptide deformylase forms containing either iron or nickel in the active site.
about
An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathwayCrystal structure of type II peptide deformylase from Staphylococcus aureusStructural variation and inhibitor binding in polypeptide deformylase from four different bacterial speciesIron center, substrate recognition and mechanism of peptide deformylaseEukaryotic peptide deformylases. Nuclear-encoded and chloroplast-targeted enzymes in ArabidopsisPeptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach.Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number.Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents.Resistance of Streptococcus pneumoniae to deformylase inhibitors is due to mutations in defB.N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activityActive site metal ion in UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) switches between Fe(II) and Zn(II) depending on cellular conditions.Peptide deformylase: a target for novel antibiotics?The crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms.Identification of crucial amino acids of bacterial Peptide deformylases affecting enzymatic activity in response to oxidative stressHigh tolerance to mutations in a Chlamydia trachomatis peptide deformylase loopPeptide deformylase inhibitors as potent antimycobacterial agents.Non-coding nucleotides and amino acids near the active site regulate peptide deformylase expression and inhibitor susceptibility in Chlamydia trachomatis.Therapeutic potential of peptide deformylase inhibitors.Zinc is the metal cofactor of Borrelia burgdorferi peptide deformylase.Delineation of alternative conformational states in Escherichia coli peptide deformylase via thermodynamic studies for the binding of actinonin.Peptide deformylase--a promising therapeutic target for tuberculosis and antibacterial drug discovery.Crystallization and preliminary X-ray crystallographic analysis of peptide deformylase (PDF) from Bacillus cereus in ligand-free and actinonin-bound forms.Effect of 4-methoxy 1-methyl 2-oxopyridine 3-carbamide on Staphylococcus aureus by inhibiting UDP-MurNAc-pentapeptide, peptidyl deformylase and uridine monophosphate kinase.Activation of Escherichia coli UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase by Fe2+ yields a more efficient enzyme with altered ligand affinity.The activity and cofactor preferences of N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) change depending on environmental conditions.Phylogenomic and biochemical characterization of three Legionella pneumophila polypeptide deformylases.Geometric preferences in iron(II) and zinc(II) model complexes of peptide deformylase.Dynamic enzyme docking to the ribosome coordinates N-terminal processing with polypeptide folding.Design and synthesis of 4'-((5-benzylidene-2,4-dioxothiazolidin-3-yl)methyl)biphenyl-2-carbonitrile analogs as bacterial peptide deformylase inhibitors.Bacterial Peptide Deformylase Inhibition of Tetrazole-Substituted Biaryl Acid Analogs: Synthesis, Biological Evaluations, and Molecular Docking Study.
P2860
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P2860
Isolation and crystallization of functionally competent Escherichia coli peptide deformylase forms containing either iron or nickel in the active site.
description
1998 nî lūn-bûn
@nan
1998 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Isolation and crystallization ...... or nickel in the active site.
@ast
Isolation and crystallization ...... or nickel in the active site.
@en
Isolation and crystallization ...... or nickel in the active site.
@nl
type
label
Isolation and crystallization ...... or nickel in the active site.
@ast
Isolation and crystallization ...... or nickel in the active site.
@en
Isolation and crystallization ...... or nickel in the active site.
@nl
prefLabel
Isolation and crystallization ...... or nickel in the active site.
@ast
Isolation and crystallization ...... or nickel in the active site.
@en
Isolation and crystallization ...... or nickel in the active site.
@nl
P2093
P356
P1476
Isolation and crystallization ...... or nickel in the active site.
@en
P2093
P304
P356
10.1006/BBRC.1998.8616
P407
P577
1998-05-01T00:00:00Z