Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations

Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations

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http://www.wikidata.org/entity/Q34475657
Identification of the molecular attributes required for aminoglycoside activity against Leishmania4′-O-substitutions determine selectivity of aminoglycoside antibioticsStructural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics.Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftorIdentification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: An update for 2011-2012.New inducible genetic method reveals critical roles of GABA in the control of feeding and metabolism.Rise and dissemination of aminoglycoside resistance: the aac(6')-Ib paradigm.Designer aminoglycosides that selectively inhibit cytoplasmic rather than mitochondrial ribosomes show decreased ototoxicity: a strategy for the treatment of genetic diseases.Nonsense Suppression as an Approach to Treat Lysosomal Storage Diseases.Targeting Nonsense Mutations in Diseases with Translational Read-Through-Inducing Drugs (TRIDs).Design of Novel Aminoglycoside Derivatives with Enhanced Suppression of Diseases-Causing Nonsense Mutations.N6', N6''', and O4' Modifications to Neomycin Affect Ribosomal Selectivity without Compromising Antibacterial Activity.When Proteins Start to Make Sense: Fine-tuning Aminoglycosides for PTC Suppression Therapy.Towards the Prevention of Aminoglycoside-Related Hearing Loss.Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.Characterization of new-generation aminoglycoside promoting premature termination codon readthrough in cancer cells.
P2860

Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations

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http://www.wikidata.org/entity/Q34475657
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2012 nî lūn-bûn
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2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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name
Increased selectivity toward c ...... s caused by nonsense mutations
@ast
Increased selectivity toward c ...... s caused by nonsense mutations
@en
Increased selectivity toward c ...... s caused by nonsense mutations
@nl
type
label
Increased selectivity toward c ...... s caused by nonsense mutations
@ast
Increased selectivity toward c ...... s caused by nonsense mutations
@en
Increased selectivity toward c ...... s caused by nonsense mutations
@nl
prefLabel
Increased selectivity toward c ...... s caused by nonsense mutations
@ast
Increased selectivity toward c ...... s caused by nonsense mutations
@en
Increased selectivity toward c ...... s caused by nonsense mutations
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P932
P356
P1433
P1476
Increased selectivity toward c ...... s caused by nonsense mutations
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P932