Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions. - Wikidata - wikimedia - TriplyDB

Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions.

Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions.

http://www.wikidata.org/entity/Q34475839

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Spatial Genome Organization and Its Emerging Role as a Potential Diagnosis Tool Roles of long noncoding RNAs in chromosome domains The Chromatin Signature of Pluripotency: Establishment and Maintenance Anchoring a Leviathan: How the Nuclear Membrane Tethers the Genome The second decade of 3C technologies: detailed insights into nuclear organization Advances in understanding - genetic basis of intellectual disability Mechanisms underlying structural variant formation in genomic disorders Understanding Spatial Genome Organization: Methods and Insights Epigenetic modulators, modifiers and mediators in cancer aetiology and progression Mechanisms of Origin, Phenotypic Effects and Diagnostic Implications of Complex Chromosome Rearrangements Minor Loops in Major Folds: Enhancer-Promoter Looping, Chromatin Restructuring, and Their Association with Transcriptional Regulation and Disease Enabling functional genomics with genome engineering Chromatin Insulators and Topological Domains: Adding New Dimensions to 3D Genome Architecture Analysis methods for studying the 3D architecture of the genome An Overview of Genome Organization and How We Got There: from FISH to Hi-C The CRISPR revolution and its impact on cancer research Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice.Active chromatin and transcription play a key role in chromosome partitioning into topologically associating domains.Entropy gives rise to topologically associating domains.A collagen VI-dependent pathogenic mechanism for Hirschsprung's disease.Effects of DNA supercoiling on chromatin architecture Using CRISPR/Cas to study gene function and model disease in vivo New insights into the generation and role of de novo mutations in health and disease Building up the nucleus: nuclear organization in the establishment of totipotency and pluripotency during mammalian development CTCF: making the right connections Genome-wide epigenomic profiling for biomarker discovery Structural and functional diversity of Topologically Associating Domains Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23 Explorations to improve the completeness of exome sequencing The cancer-associated CTCFL/BORIS protein targets multiple classes of genomic repeats, with a distinct binding and functional preference for humanoid-specific SVA transposable elements Regulatory landscape fusion in rhabdomyosarcoma through interactions between the PAX3 promoter and FOXO1 regulatory elements HiCPlotter integrates genomic data with interaction matrices.Phenotypic subregions within the split-hand/foot malformation 1 locus.3Disease Browser: A Web server for integrating 3D genome and disease-associated chromosome rearrangement data.Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes.Different enhancer classes in Drosophila bind distinct architectural proteins and mediate unique chromatin interactions and 3D architecture Enhancers and chromatin structures: regulatory hubs in gene expression and diseases.The Wilms tumor protein Wt1 contributes to female fertility by regulating oviductal proteostasis.Functional assessment of CTCF sites at cytokine-sensing mammary enhancers using CRISPR/Cas9 gene editing in mice Tracking the evolution of 3D gene organization demonstrates its connection to phenotypic divergence

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P2860

Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions.

http://www.wikidata.org/entity/Q34475839

description

2015 nî lūn-bûn

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2015 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2015 թվականի մայիսին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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Disruptions of topological chr ...... of gene-enhancer interactions.

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Disruptions of topological chr ...... of gene-enhancer interactions.

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Disruptions of topological chr ...... of gene-enhancer interactions.

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Disruptions of topological chr ...... of gene-enhancer interactions.

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Disruptions of topological chr ...... of gene-enhancer interactions.

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Disruptions of topological chr ...... of gene-enhancer interactions.

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Disruptions of topological chr ...... of gene-enhancer interactions.

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Disruptions of topological chr ...... of gene-enhancer interactions.

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Disruptions of topological chr ...... of gene-enhancer interactions.

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J.CELL.2015.04.004

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Bernd Timmermann

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Denise Horn

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Fernando Santos-Simarro

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Francesco Brancati

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Jochen Hecht

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John M Opitz

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Lars Wittler

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Marina Borschiwer

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Renata Laxova

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Stefan Mundlos

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Genomic views of distant-acting enhancers

Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

VISTA Enhancer Browser--a database of tissue-specific human enhancers

DECIPHER: web-based, community resource for clinical interpretation of rare variants in developmental disorders

Impacts of variation in the human genome on gene regulation

Comprehensive mapping of long-range interactions reveals folding principles of the human genome

ChIP-seq accurately predicts tissue-specific activity of enhancers

Topological domains in mammalian genomes identified by analysis of chromatin interactions

The ENCODE (ENCyclopedia Of DNA Elements) Project

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161

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Hülya Kayserili

Malte Spielmann

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Darío G. Lupiáñez

Brigitte Gilbert-Dussardier

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2015-05-07T00:00:00Z

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276149332

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