Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation.
about
Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissuesEmerging role of mast cells and macrophages in cardiovascular and metabolic diseasesThe lysosome: from waste bag to potential therapeutic targetNovel biological markers of bone: from bone metabolism to bone physiologyCathepsin K inhibitors for osteoporosis and potential off-target effectsData on gene and protein expression changes induced by apabetalone (RVX-208) in ex vivo treated human whole blood and primary hepatocytes.Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat storesSystematic optimization of multiplex zymography protocol to detect active cathepsins K, L, S, and V in healthy and diseased tissue: compromise among limits of detection, reduced time, and resources.Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processesThe arterial microenvironment: the where and why of atherosclerosis.Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profileInnate and adaptive immunity in atherosclerosis.Pro-atherogenic shear stress and HIV proteins synergistically upregulate cathepsin K in endothelial cells.Increased serum cathepsin K in patients with coronary artery disease.Leukocyte cathepsin C deficiency attenuates atherosclerotic lesion progression by selective tuning of innate and adaptive immune responses.Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formationCysteinyl cathepsins and mast cell proteases in the pathogenesis and therapeutics of cardiovascular diseases.IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice.Cathepsin Gene Family Reveals Transcriptome Patterns Related to the Infective Stages of the Salmon Louse Caligus rogercresseyi.Cathepsin K deficiency reduces elastase perfusion-induced abdominal aortic aneurysms in mice.Increased Circulating Cathepsin K in Patients with Chronic Heart FailureEndothelial dysfunction, arterial stiffening, and intima-media thickening in large arteries from HIV-1 transgenic miceCysteine Protease Cathepsins in Atherosclerosis and Abdominal Aortic Aneurysm.Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in miceTumor necrosis factor alpha stimulates cathepsin K and V activity via juxtacrine monocyte-endothelial cell signaling and JNK activation.Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE-/- Mice.Cathepsin S cannibalism of cathepsin K as a mechanism to reduce type I collagen degradation.Cysteinyl cathepsins: multifunctional enzymes in cardiovascular disease.Elevated levels of endothelial-derived microparticles, and serum CXCL9 and SCGF-β are associated with unstable asymptomatic carotid plaques.Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells.Cystatin C and asymptomatic coronary artery disease in patients with metabolic syndrome and normal glomerular filtration rate.Patient specific proteolytic activity of monocyte-derived macrophages and osteoclasts predicted with temporal kinase activation states during differentiation.Low-Cost Method to Monitor Patient Adherence to HIV Antiretroviral Therapy Using Multiplex Cathepsin ZymographyEndothelial cells and cathepsins: Biochemical and biomechanical regulation.Role of matrix metalloproteinase-8 in atherosclerosisAllergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice.Cysteine cathepsin S as an immunomodulatory target: present and future trends.Plasma levels of cathepsins L, K, and V and risks of abdominal aortic aneurysms: a randomized population-based study.Levels of cathepsins in acute myocardial infarctionFuture of anticathepsin K drugs: dual therapy for skeletal disease and atherosclerosis?
P2860
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P2860
Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation.
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Disruption of the cathepsin K ...... acrophage foam cell formation.
@ast
Disruption of the cathepsin K ...... acrophage foam cell formation.
@en
Disruption of the cathepsin K ...... acrophage foam cell formation.
@nl
type
label
Disruption of the cathepsin K ...... acrophage foam cell formation.
@ast
Disruption of the cathepsin K ...... acrophage foam cell formation.
@en
Disruption of the cathepsin K ...... acrophage foam cell formation.
@nl
prefLabel
Disruption of the cathepsin K ...... acrophage foam cell formation.
@ast
Disruption of the cathepsin K ...... acrophage foam cell formation.
@en
Disruption of the cathepsin K ...... acrophage foam cell formation.
@nl
P2093
P1433
P1476
Disruption of the cathepsin K ...... acrophage foam cell formation.
@en
P2093
Cleutjens KB
Daugherty A
Frederik P
Gijbels MM
Heeneman S
P304
P356
10.1161/CIRCULATIONAHA.105.561449
P407
P577
2005-12-19T00:00:00Z