Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation.
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Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetasesThe Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monooxygenase Complexed with Octane Discloses Several Structural Adaptations for ω-Hydroxylation.Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment.Disruption of the Sjögren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier RecoveryPNPLA1 Deficiency in Mice and Humans Leads to a Defect in the Synthesis of Omega-O-Acylceramides.PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis.The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways.Meibomian glands, meibum, and meibogenesis.PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier.Topically applied fatty acids are elongated before incorporation in the stratum corneum lipid matrix in compromised skin.Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide.Biallelic Mutations in KDSR Disrupt Ceramide Synthesis and Result in a Spectrum of Keratinization Disorders Associated with Thrombocytopenia.Coffee polyphenols extracted from green coffee beans improve skin properties and microcirculatory function.Expression and Functional Characterization of Breast Cancer-Associated Cytochrome P450 4Z1 in Saccharomyces cerevisiae.Inherited Nonsyndromic Ichthyoses: An Update on Pathophysiology, Diagnosis and Treatment.Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates trans-retinol to 3,4-dehydroretinol.Ichthyoses: new insights unravel defects in skin barrier function resulting in diverse clinical and morphological phenotypes.Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function.Fatty acids and related lipid mediators in the regulation of cutaneous inflammation.Morphological alterations in two siblings with autosomal recessive congenital ichthyosis associated with CYP4F22 mutations.Two missense mutations in CYP4F22 in autosomal recessive congenital ichthyosis.Noncovalent interactions dominate dynamic heme distortion in cytochrome P450 4B1
P2860
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P2860
Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation.
description
2015 nî lūn-bûn
@nan
2015 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Essential role of the cytochro ...... ermeability barrier formation.
@ast
Essential role of the cytochro ...... ermeability barrier formation.
@en
Essential role of the cytochro ...... ermeability barrier formation.
@nl
type
label
Essential role of the cytochro ...... ermeability barrier formation.
@ast
Essential role of the cytochro ...... ermeability barrier formation.
@en
Essential role of the cytochro ...... ermeability barrier formation.
@nl
prefLabel
Essential role of the cytochro ...... ermeability barrier formation.
@ast
Essential role of the cytochro ...... ermeability barrier formation.
@en
Essential role of the cytochro ...... ermeability barrier formation.
@nl
P2093
P2860
P50
P356
P1476
Essential role of the cytochro ...... ermeability barrier formation.
@en
P2093
Aya Ohkuni
Ayano Naoe
Hisashi Tsujimura
Junko Ishikawa
Kazumitsu Sugiura
Masashi Akiyama
Nozomi Kamiyama
Shota Nakamichi
P2860
P304
P356
10.1073/PNAS.1503491112
P407
P577
2015-06-08T00:00:00Z