Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations.
about
Keeping mtDNA in shape between generationsMeasuring stem cell dynamics in the human colon--where there's a wiggle, there's a wayThe landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selectionThe role of the mitochondrial ribosome in human disease: searching for mutations in 12S mitochondrial rRNA with high disruptive potential.A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease.Control of mitochondrial integrity in ageing and diseaseSimilar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humansClonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.Aging: A mitochondrial DNA perspective, critical analysis and an update.Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damageSomatic mtDNA mutation spectra in the aging human putamen.Human stem cell aging: do mitochondrial DNA mutations have a causal role?The pleiotropic effect of physical exercise on mitochondrial dynamics in aging skeletal muscle.Parkinson's disease: a complex interplay of mitochondrial DNA alterations and oxidative stress.Germline mitochondrial DNA mutations aggravate ageing and can impair brain development.Heteroplasmic shifts in tumor mitochondrial genomes reveal tissue-specific signals of relaxed and positive selection.Capture of somatic mtDNA point mutations with severe effects on oxidative phosphorylation in synaptosome cybrid clones from human brain.Intracellular evolution of mitochondrial DNA (mtDNA) and the tragedy of the cytoplasmic commons.The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.Roles of Mitochondrial DNA Mutations in Stem Cell Ageing.Impact of nutrition on the ageing process.Brain Energy and Oxygen Metabolism: Emerging Role in Normal Function and Disease.
P2860
Q21092400-9749206B-7597-4C2F-8251-8D649632D1B6Q26824890-BF3C93DF-10A5-4C7A-9FAB-6A2ED9EC06F4Q28389979-F1EFF3C7-7A48-4817-BA9D-29EBFFB6C6E4Q30567357-6039F048-D992-4DA1-BAB8-32E26A098AE8Q33640086-8558FBD5-5B02-4BFE-BFFA-73A0F529C3C3Q33655966-37826078-0895-4342-B5D6-8A776A7380A3Q34079011-595C05A1-803E-4054-9B88-9E14B0B09D51Q34213867-E4BA0708-A3A2-4CEE-9952-8297ADAFD9EAQ34543522-4DD8FBD6-D545-48EB-ABA3-B079197897C3Q35004513-551001E6-81A7-419C-BD2B-3069D0A03F1DQ35067263-7733F896-3418-4B01-8ADB-22605BDE92D3Q35093139-A7AA3AA6-66B0-4F24-A9CB-E797B7EB3435Q35471306-4C22F01C-8510-4EC3-9A1B-60E8D92828ECQ36655956-A8A13BCF-DC30-4191-B794-2AAEBD7FAF92Q37288018-0647DDB2-E3D3-45A4-A54B-0DC87BB13976Q38802081-DC8EC8B8-3AF5-4C2A-A80A-DEC2B7569EF7Q48545022-A2A2370C-C25D-4DB6-8781-1F3880D18830Q50910700-D41F5B73-B5F9-4F7F-BFB2-78CD4C26D1B7Q50994607-4B9CF029-5EA0-4404-A226-14C3B7ECDB98Q51759033-12FCC2C7-F92C-4F7D-B10C-6F1A6148968AQ51771504-39AA7F65-122F-4164-AC9C-C8F93E2F15F4Q55514851-44A2B661-9F7F-45F1-8EC0-36DE4766DD6E
P2860
Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations.
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Comparison of mitochondrial mu ...... chondrial DNA point mutations.
@ast
Comparison of mitochondrial mu ...... chondrial DNA point mutations.
@en
Comparison of mitochondrial mu ...... chondrial DNA point mutations.
@nl
type
label
Comparison of mitochondrial mu ...... chondrial DNA point mutations.
@ast
Comparison of mitochondrial mu ...... chondrial DNA point mutations.
@en
Comparison of mitochondrial mu ...... chondrial DNA point mutations.
@nl
prefLabel
Comparison of mitochondrial mu ...... chondrial DNA point mutations.
@ast
Comparison of mitochondrial mu ...... chondrial DNA point mutations.
@en
Comparison of mitochondrial mu ...... chondrial DNA point mutations.
@nl
P2093
P2860
P50
P1433
P1476
Comparison of mitochondrial mu ...... chondrial DNA point mutations.
@en
P2093
Geoffrey A Taylor
Joanna L Elson
Marco Nooteboom
Robert W Taylor
P2860
P304
P356
10.1371/JOURNAL.PGEN.1003082
P577
2012-11-15T00:00:00Z