High affinity humanized antibodies without making hybridomas; immunization paired with mammalian cell display and in vitro somatic hypermutation
about
Therapeutic antibody engineering by high efficiency cell screening.Generation of Recombinant Monoclonal Antibodies from Immunised Mice and Rabbits via Flow Cytometry and Sorting of Antigen-Specific IgG+ Memory B Cells.Humanization of antibodies using heavy chain complementarity-determining region 3 grafting coupled with in vitro somatic hypermutationA general approach to antibody thermostabilization.Simultaneous surface display and secretion of proteins from mammalian cells facilitate efficient in vitro selection and maturation of antibodies.Identification of high affinity HER2 binding antibodies using CHO Fab surface display.Coupling recombinase-mediated cassette exchange with somatic hypermutation for antibody affinity maturation in CHO cells.Transient AID expression for in situ mutagenesis with improved cellular fitness.
P2860
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P2860
High affinity humanized antibodies without making hybridomas; immunization paired with mammalian cell display and in vitro somatic hypermutation
description
2012 nî lūn-bûn
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2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
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2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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name
High affinity humanized antibo ...... in vitro somatic hypermutation
@ast
High affinity humanized antibo ...... in vitro somatic hypermutation
@en
High affinity humanized antibo ...... in vitro somatic hypermutation
@nl
type
label
High affinity humanized antibo ...... in vitro somatic hypermutation
@ast
High affinity humanized antibo ...... in vitro somatic hypermutation
@en
High affinity humanized antibo ...... in vitro somatic hypermutation
@nl
prefLabel
High affinity humanized antibo ...... in vitro somatic hypermutation
@ast
High affinity humanized antibo ...... in vitro somatic hypermutation
@en
High affinity humanized antibo ...... in vitro somatic hypermutation
@nl
P2093
P2860
P1433
P1476
High affinity humanized antibo ...... in vitro somatic hypermutation
@en
P2093
Andy P Chen
Ashley D Berkebile
Audrey D McConnell
David J King
John L Macomber
Josh MacLaren
Laurence Altobell
Peter M Bowers
Robert A Horlick
P2860
P304
P356
10.1371/JOURNAL.PONE.0049458
P407
P577
2012-11-14T00:00:00Z