PA-824 exhibits time-dependent activity in a murine model of tuberculosis. - Wikidata - wikimedia - TriplyDB

PA-824 exhibits time-dependent activity in a murine model of tuberculosis.

PA-824 exhibits time-dependent activity in a murine model of tuberculosis.

http://www.wikidata.org/entity/Q34483632

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Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis The R enantiomer of the antitubercular drug PA-824 as a potential oral treatment for visceral Leishmaniasis.Novel regimens identified in mice for treatment of latent tuberculosis infection in contacts of patients with multidrug-resistant tuberculosis Pharmacokinetic and pharmacodynamic evaluation of AZD5847 in a mouse model of tuberculosis.Phase I safety, pharmacokinetics, and pharmacogenetics study of the antituberculosis drug PA-824 with concomitant lopinavir-ritonavir, efavirenz, or rifampin.PA-824 is as effective as isoniazid against latent tuberculosis infection in C3HeB/FeJ mice In vitro and in vivo activities of the nitroimidazole TBA-354 against Mycobacterium tuberculosis Bactericidal activity of PA-824 against Mycobacterium tuberculosis under anaerobic conditions and computational analysis of its novel analogues against mutant Ddn receptor Carbon-14 radiolabeling and in vivo biodistribution of a potential anti-TB compound.Impact of Fgd1 and ddn diversity in Mycobacterium tuberculosis complex on in vitro susceptibility to PA-824.Sterilizing activity of novel TMC207- and PA-824-containing regimens in a murine model of tuberculosis Pharmacokinetics and pharmacodynamics of TMC207 and its N-desmethyl metabolite in a murine model of tuberculosis.Computational pharmacokinetics/pharmacodynamics of rifampin in a mouse tuberculosis infection model In silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatment Phase II dose-ranging trial of the early bactericidal activity of PA-824 A physiologically based pharmacokinetic model of rifampin in mice.Potent rifamycin-sparing regimen cures guinea pig tuberculosis as rapidly as the standard regimen Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice.Antituberculosis drug research: a critical overview.New treatment options for multidrug-resistant tuberculosis.Antimycobacterial drugs currently in Phase II clinical trials and preclinical phase for tuberculosis treatment.Targeting the mycobacterial envelope for tuberculosis drug development.PA-824 , moxifloxacin and pyrazinamide combination therapy for tuberculosis.Pharmacokinetic-pharmacodynamic and dose-response relationships of antituberculosis drugs: recommendations and standards for industry and academia.Encapsulation of Anti-Tuberculosis Drugs within Mesoporous Silica and Intracellular Antibacterial Activities.Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents.Cordyceps sinensis promotes immune regulation and enhances bacteriostatic activity of PA-824 via IL-10 in Mycobacterium tuberculosis disease.Treatment of Tuberculosis. A Historical Perspective.Pharmacokinetics and pharmacogenetics of anti-tubercular drugs: a tool for treatment optimization?Modeling and Simulation of Pretomanid Pharmacokinetics in Pulmonary Tuberculosis Patients.

P2860

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P2860

PA-824 exhibits time-dependent activity in a murine model of tuberculosis.

http://www.wikidata.org/entity/Q34483632

description

2010 nî lūn-bûn

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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

PA-824 exhibits time-dependent activity in a murine model of tuberculosis.

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PA-824 exhibits time-dependent activity in a murine model of tuberculosis.

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PA-824 exhibits time-dependent activity in a murine model of tuberculosis.

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type

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PA-824 exhibits time-dependent activity in a murine model of tuberculosis.

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PA-824 exhibits time-dependent activity in a murine model of tuberculosis.

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PA-824 exhibits time-dependent activity in a murine model of tuberculosis.

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prefLabel

PA-824 exhibits time-dependent activity in a murine model of tuberculosis.

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PA-824 exhibits time-dependent activity in a murine model of tuberculosis.

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PA-824 exhibits time-dependent activity in a murine model of tuberculosis.

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Antimicrobial Agents and Chemotherapy

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PA-824 exhibits time-dependent activity in a murine model of tuberculosis.

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P2093

Ann Ginsberg

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Charles A Peloquin

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Eric L Nuermberger

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Hartmut Derendorf

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Jacques H Grosset

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Rajendra P Singh

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Sandeep Tyagi

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Zahoor Ahmad

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P2860

OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice

Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model

Safety, tolerability, and pharmacokinetics of PA-824 in healthy subjects

The mechanism of action of PA-824: Novel insights from transcriptional profiling

PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release

A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

Comparison of the 'Denver regimen' against acute tuberculosis in the mouse and guinea pig.

Bactericidal activity of the nitroimidazopyran PA-824 in a murine model of tuberculosis.

Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models.

Early bactericidal activity and pharmacokinetics of PA-824 in smear-positive tuberculosis patients

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10.1128/AAC.00849-10

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Akafuba bulwadde

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