about
Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4Important role of the cys-191 cys-220 disulfide bond in thrombin function and allosteryStructural identification of the pathway of long-range communication in an allosteric enzymeCrystal Structure of Thrombin Bound to the Uncleaved Extracellular Fragment of PAR1Rigidification of the autolysis loop enhances Na+ binding to thrombinSelection of an aptamer antidote to the anticoagulant drug bivalirudinRemote exosites of the catalytic domain of matrix metalloproteinase-12 enhance elastin degradation.Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis.Apolipoprotein-E forms dimers in human frontal cortex and hippocampusEngineering thrombin for selective specificity toward protein C and PAR1.NMR and bioinformatics discovery of exosites that tune metalloelastase specificity for solubilized elastin and collagen triple helices.Allosteric networks in thrombin distinguish procoagulant vs. anticoagulant activities.Thrombomodulin Binding Selects the Catalytically Active Form of ThrombinSingle-step selection of bivalent aptamers validated by comparison with SELEX using high-throughput sequencingDabigatran and Argatroban Diametrically Modulate Thrombin Exosite FunctionExpression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation.Thrombin.Exosites in the substrate specificity of blood coagulation reactions.Impact of moderate blast exposures on thrombin biomarkers assessed by calibrated automated thrombography in rats.Looking at the proteases from a simple perspective.Identification of a new exosite involved in catalytic turnover by the streptokinase-plasmin activator complex during human plasminogen activation.Protamine-adsorbed magnetic nanoparticles for efficient isolation and concentration of hepatitis-C virus from human plasma samples.Comparative binding energy analysis for binding affinity and target selectivity prediction.Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4.Identification and Antithrombotic Activity of Peptides from Blue Mussel (Mytilus edulis) ProteinSize and surface charge significantly influence the toxicity of silica and dendritic nanoparticles.Molecular dynamics simulations of aptamer-binding reveal generalized allostery in thrombin.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Structure and interaction modes of thrombin.
@ast
Structure and interaction modes of thrombin.
@en
Structure and interaction modes of thrombin.
@nl
type
label
Structure and interaction modes of thrombin.
@ast
Structure and interaction modes of thrombin.
@en
Structure and interaction modes of thrombin.
@nl
prefLabel
Structure and interaction modes of thrombin.
@ast
Structure and interaction modes of thrombin.
@en
Structure and interaction modes of thrombin.
@nl
P1476
Structure and interaction modes of thrombin.
@en
P304
P356
10.1016/J.BCMD.2005.12.027
P50
P577
2006-02-15T00:00:00Z