Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis. - Wikidata - wikimedia - TriplyDB

Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.

Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.

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Species-Specific and Inhibitor-Dependent Conformations of LpxC: Implications for Antibiotic Design Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold Structural–Functional Studies of Burkholderia cenocepacia d -Glycero-β- d -manno-heptose 7-Phosphate Kinase (HldA) and Characterization of Inhibitors with Antibiotic Adjuvant and Antivirulence Properties Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors Structure of the Bacterial Deacetylase LpxC Bound to the Nucleotide Reaction Product Reveals Mechanisms of Oxyanion Stabilization and Proton Transfer Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC A Complete Pathway Model for Lipid A Biosynthesis in Escherichia coli The UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis utilizes Mn2+ cluster for catalysis.Lipopolysaccharide transport to the cell surface: periplasmic transport and assembly into the outer membrane.Gonorrhea - an evolving disease of the new millennium.Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis.Genomewide identification of genetic determinants of antimicrobial drug resistance in Pseudomonas aeruginosa 3D-QSAR, Molecular Docking and Molecular Dynamics Simulation of Pseudomonas aeruginosa LpxC Inhibitors Drug-target residence time: critical information for lead optimization.DNA recognition by a σ(54) transcriptional activator from Aquifex aeolicus Validation of inhibitors of an ABC transporter required to transport lipopolysaccharide to the cell surface in Escherichia coli.Translating slow-binding inhibition kinetics into cellular and in vivo effects Transposon Mutagenesis Paired with Deep Sequencing of Caulobacter crescentus under Uranium Stress Reveals Genes Essential for Detoxification and Stress Tolerance Toxic Accumulation of LPS Pathway Intermediates Underlies the Requirement of LpxH for Growth of Acinetobacter baumannii ATCC 19606.Novel cationic peptide TP359 down-regulates the expression of outer membrane biogenesis genes in Pseudomonas aeruginosa: a potential TP359 anti-microbial mechanism.Enzyme Tunnels and Gates As Relevant Targets in Drug Design.Helicobacter pylori Resists the Antimicrobial Activity of Calprotectin via Lipid A Modification and Associated Biofilm Formation.Inhibition of LpxC protects mice from resistant Acinetobacter baumannii by modulating inflammation and enhancing phagocytosis Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis.Drug design from the cryptic inhibitor envelope.Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biogenesis in Escherichia coli.Assignment of 1H, 13C and 15N backbone resonances of Escherichia coli LpxC bound to L-161,240 Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis A new class of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitors for the treatment of Gram-negative infections: PCT application WO 2008027466.Drug Target Identification and Elucidation of Natural Inhibitors for Bordetella petrii: An In Silico Study.Understanding efflux in Gram-negative bacteria: opportunities for drug discovery.Update on carbohydrate-containing antibacterial agents.New antibacterial agents: patent applications published in 2011.Characterization of an Acinetobacter baumannii lptD Deletion Strain: Permeability Defects and Response to Inhibition of Lipopolysaccharide and Fatty Acid Biosynthesis.Using bacterial genomes and essential genes for the development of new antibiotics.Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors.In Vitro and In Vivo Efficacy of an LpxC Inhibitor, CHIR-090, Alone or Combined with Colistin against Pseudomonas aeruginosa Biofilm.LpxC Inhibitors as Effective Therapy Against Multidrug Resistant Bacterial Infections.LpxK Is Essential for Growth of Acinetobacter baumannii ATCC 19606: Relationship to Toxic Accumulation of Lipid A Pathway Intermediates.

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Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.

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2008 nî lūn-bûn

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2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2008 թվականի փետրվարին հրատարակված գիտական հոդված

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2008年の論文

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Mechanism and inhibition of Lp ...... f bacterial lipid A synthesis.

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Mechanism and inhibition of Lp ...... f bacterial lipid A synthesis.

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Mechanism and inhibition of Lp ...... f bacterial lipid A synthesis.

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P2860

Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Toll-like receptors in the induction of the innate immune response

Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway.

Antibacterial activities and characterization of novel inhibitors of LpxC.

Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC.

UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme.

Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design.

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism.

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