Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens.
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The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalisHyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylationTransgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaksAldose reductase deficiency protects sugar-induced lens opacification in ratsThe Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-QuinonesOxidative stress and diabetic complicationsSpecific detections of the early process of the glycation reaction by fructose and glucose in diabetic rat lens.Exclusion of NFAT5 from mitotic chromatin resets its nucleo-cytoplasmic distribution in interphase.Structure based comprehensive modelling, spatial fingerprints mapping and ADME screening of curcumin analogues as novel ALR2 inhibitors.Aldo-keto reductases in the eye.Molecular genetics of age-related cataract.Effects of asymmetric dimethylarginine on bovine retinal capillary endothelial cell proliferation, reactive oxygen species production, permeability, intercellular adhesion molecule-1, and occludin expression.The mousetrap: what we can learn when the mouse model does not mimic the human disease.Evaluation of the aldose reductase inhibitor fidarestat on ischemia-reperfusion injury in rat retina.Topical KINOSTAT™ ameliorates the clinical development and progression of cataracts in dogs with diabetes mellitus.ALDOSE REDUCTASE: New Insights for an Old Enzyme.Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders.Osmostress-induced apoptosis in Xenopus oocytes: role of stress protein kinases, calpains and Smac/DIABLO.Aldose reductase expression as a risk factor for cataractCytomorphometric study of epithelial cells in normal and cataractous human lenses in relation with hyperglycemia.Potential new strategies to prevent the development of diabetic retinopathy.Featured Article: Inhibition of diabetic cataract by glucose tolerance factor extracted from yeast.Aldose reductase, oxidative stress, and diabetic mellitus.Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells.RNA sequencing for global gene expression associated with muscle growth in a single male modern broiler line compared to a foundational Barred Plymouth Rock chicken lineReactive oxygen species, reactive nitrogen species and antioxidants in etiopathogenesis of diabetes mellitus type-2Reduction of oxidative-nitrosative stress underlies anticataract effect of topically applied tocotrienol in streptozotocin-induced diabetic ratsTissue-specific expression of two aldose reductase-like genes in mice: abundant expression of mouse vas deferens protein and fibroblast growth factor-regulated protein in the adrenal glandAldose reductase mediates retinal microglia activation.Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis.Propolis, a Constituent of Honey, Inhibits the Development of Sugar Cataracts and High-Glucose-Induced Reactive Oxygen Species in Rat Lenses.Cinnamaldehyde Attenuates Cataractogenesis via Restoration of Hypertension and Oxidative Stress in Fructose-Fed Hypertensive ratsThe polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient.ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells.Aldo-keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels.Gender difference in the association of metabolic syndrome and its components with age-related cataract: the Korea National Health and Nutrition Examination Survey 2008-2010Inherited metabolic disorders involving the eye: a clinico-biochemical perspective.Aldose reductase and cardiovascular diseases, creating human-like diabetic complications in an experimental model.Clinical science review article: understanding the implications of diabetes on the vascular system.Lens Biology and Biochemistry
P2860
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P2860
Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens.
description
1995 nî lūn-bûn
@nan
1995 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի մարտին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Demonstration that polyol accu ...... se reductase gene in the lens.
@ast
Demonstration that polyol accu ...... se reductase gene in the lens.
@en
Demonstration that polyol accu ...... se reductase gene in the lens.
@nl
type
label
Demonstration that polyol accu ...... se reductase gene in the lens.
@ast
Demonstration that polyol accu ...... se reductase gene in the lens.
@en
Demonstration that polyol accu ...... se reductase gene in the lens.
@nl
prefLabel
Demonstration that polyol accu ...... se reductase gene in the lens.
@ast
Demonstration that polyol accu ...... se reductase gene in the lens.
@en
Demonstration that polyol accu ...... se reductase gene in the lens.
@nl
P2093
P2860
P356
P1476
Demonstration that polyol accu ...... se reductase gene in the lens.
@en
P2093
P2860
P304
P356
10.1073/PNAS.92.7.2780
P407
P577
1995-03-01T00:00:00Z