TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells.
about
The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channelsANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteinsCFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cellsCFTR and TMEM16A are separate but functionally related Cl- channelsAnoctamin-6 controls bone mineralization by activating the calcium transporter NCX1Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signalingNovel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway DiseasesHigh throughput screening technologies for ion channelsThe bestrophin- and TMEM16A-associated Ca(2+)- activated Cl(–) channels in vascular smooth musclesThe Ca(2+) -activated Cl(-) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesisEffects of Small Molecule Calcium-Activated Chloride Channel Inhibitors on Structure and Function of Accessory Cholera Enterotoxin (Ace) of Vibrio choleraeAntagonists of the TMEM16A calcium-activated chloride channel modulate airway smooth muscle tone and intracellular calcium.A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipidCellular functions of TMEM16/anoctaminFractionation of a herbal antidiarrheal medicine reveals eugenol as an inhibitor of Ca2+-Activated Cl- channel TMEM16AAntidiarrheal efficacy and cellular mechanisms of a Thai herbal remedyInhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell LinesAni9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2Mechanism of allosteric activation of TMEM16A/ANO1 channels by a commonly used chloride channel blockerVariomics screen identifies the re-entrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation.The Concise Guide to PHARMACOLOGY 2013/14: ion channelsAnoctamin-1 Cl(-) channels in nociception: activation by an N-aroylaminothiazole and capsaicin and inhibition by T16A[inh]-A01Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal miceNanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases.Cellular distribution and function of ion channels involved in transport processes in rat tracheal epithelium.Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptorAnoctamins.International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels.Physiology of epithelial chloride and fluid secretionCFTR inhibitors.Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion.Novel amino-carbonitrile-pyrazole identified in a small molecule screen activates wild-type and ΔF508 cystic fibrosis transmembrane conductance regulator in the absence of a cAMP agonistPresynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina.Identification and characterization of a novel promoter for the human ANO1 gene regulated by the transcription factor signal transducer and activator of transcription 6 (STAT6)Microfluidics platform for single-shot dose-response analysis of chloride channel-modulating compoundsCharacterization of Cardiac Anoctamin1 Ca²⁺-Activated Chloride Channels and Functional Role in Ischemia-Induced ArrhythmiasFunctional apical large conductance, Ca2+-activated, and voltage-dependent K+ channels are required for maintenance of airway surface liquid volume.Glucose stimulates calcium-activated chloride secretion in small intestinal cells.Anoctamin 6 regulates C2C12 myoblast proliferationFour basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels.
P2860
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P2860
TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
TMEM16A inhibitors reveal TMEM ...... d intestinal epithelial cells.
@ast
TMEM16A inhibitors reveal TMEM ...... d intestinal epithelial cells.
@en
TMEM16A inhibitors reveal TMEM ...... d intestinal epithelial cells.
@nl
type
label
TMEM16A inhibitors reveal TMEM ...... d intestinal epithelial cells.
@ast
TMEM16A inhibitors reveal TMEM ...... d intestinal epithelial cells.
@en
TMEM16A inhibitors reveal TMEM ...... d intestinal epithelial cells.
@nl
prefLabel
TMEM16A inhibitors reveal TMEM ...... d intestinal epithelial cells.
@ast
TMEM16A inhibitors reveal TMEM ...... d intestinal epithelial cells.
@en
TMEM16A inhibitors reveal TMEM ...... d intestinal epithelial cells.
@nl
P2093
P2860
P356
P1476
TMEM16A inhibitors reveal TMEM ...... d intestinal epithelial cells.
@en
P2093
A S Verkman
Puay-Wah Phuan
Wan Namkung
P2860
P304
P356
10.1074/JBC.M110.175109
P407
P577
2010-11-17T00:00:00Z