Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove.
about
DNA and the chromosome - varied targets for chemotherapyCancer wars: natural products strike backAlkaloids from marine invertebrates as important leads for anticancer drugs discovery and developmentEcteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cellsA structural insight into major groove directed binding of nitrosourea derivative nimustine with DNA: a spectroscopic studyVon Hippel-Lindau-coupled and transcription-coupled nucleotide excision repair-dependent degradation of RNA polymerase II in response to trabectedin.Phase I combination study of trabectedin and doxorubicin in patients with soft-tissue sarcoma.Efficacy and safety of trabectedin or dacarbazine in patients with advanced uterine leiomyosarcoma after failure of anthracycline-based chemotherapy: Subgroup analysis of a phase 3, randomized clinical trial.Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growthRole of trabectedin in the treatment of soft tissue sarcomaEfficacy of trabectedin in patients with advanced or metastatic alveolar soft-part sarcoma.Preclinical and clinical results with the natural marine product ET-743.Long-term outcome and effect of maintenance therapy in patients with advanced sarcoma treated with trabectedin: an analysis of 181 patients of the French ATU compassionate use program.Mechanism-based pharmacokinetic/pharmacodynamic meta-analysis of trabectedin (ET-743, Yondelis) induced neutropenia.Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743.Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complexTrabectedin therapy as an emerging treatment strategy for recurrent platinum-sensitive ovarian cancerInduced topological changes in DNA complexes: influence of DNA sequences and small molecule structures.Diepoxybutane interstrand cross-links induce DNA bending.Ecteinascidin-743: evidence of activity in advanced, pretreated soft tissue and bone sarcoma patientsEcteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation.Current status on marine products with reversal effect on cancer multidrug resistance.A Phase II study of trabectedin single agent in patients with recurrent ovarian cancer previously treated with platinum-based regimens.New drugs for the treatment of metastatic or refractory soft tissue sarcomas in children.Isolation and characterization of an IGROV-1 human ovarian cancer cell line made resistant to Ecteinascidin-743 (ET-743).Trabectedin (ET-743): evaluation of its use in advanced soft-tissue sarcoma.A phase I study of the safety and pharmacokinetics of trabectedin in combination with pegylated liposomal doxorubicin in patients with advanced malignancies.Trabectedin in metastatic soft tissue sarcomas: Role of pretreatment and age.Phase I study of the safety and pharmacokinetics of trabectedin with docetaxel in patients with advanced malignanciesEfficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial.Large, sequence-dependent effects on DNA conformation by minor groove binding compounds.Update on the role of trabectedin in the treatment of intractable soft tissue sarcomasCurrent treatment and clinical trials in ovarian cancer.New therapies in soft tissue sarcoma.Wide-spectrum characterization of trabectedin: biology, clinical activity and future perspectives.Novel drugs from marine microorganisms.Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics.Minor groove to major groove, an unusual DNA sequence-dependent change in bend directionality by a distamycin dimerRegulation of transcription by synthetic DNA-bending agents.In vitro interaction between ecteinascidin 743 (ET-743) and radiation, in relation to its cell cycle effects
P2860
Q24792540-D43DE040-F5F9-47BF-A5AA-56EEDA480A2BQ26850074-EF3EB386-4BE1-4D6D-96C1-E9ED0E30BEF1Q27012072-E0B02B81-7E15-403E-A1EB-A24FBD0518DBQ28307320-2F234EA9-5464-4768-B0D7-506209F1092BQ28541713-56F65A8E-765F-4C55-9960-1BFFAD38FB55Q33377399-FC403228-9B92-4ADB-9921-F523CAC34D4BQ33381641-3FB491A6-4446-49E0-9677-67BFE6C2ACD4Q33442984-E8E1A456-1261-42F3-B10E-8FC2EF5CE045Q33904684-DB2B5826-2D26-45E1-B130-2B4CA09E2B5AQ33916011-469C3BA9-A655-4865-A17E-59CED70BB799Q34368039-15EEC0A8-9285-4120-8A20-E780F8D1D558Q34542908-49648DFD-8E35-46C0-86F3-707E813EF2F2Q34578850-48EF7036-F43D-4ADA-BD62-E8EDDF66EA96Q34580659-82EF3271-4548-40D9-9305-1E9804351F8EQ34581388-43500150-675F-4078-B152-DC08E11B5CA7Q34594349-C8F9AFC9-A1F7-4D0D-836F-4A64C3C53FE3Q34996149-5AA138E6-D4E6-409B-8809-C6EF0F68EA22Q35017815-95DF21FA-1DC2-4FE6-8309-209CF4DDA4F5Q35608561-1AFC881C-AC42-43DD-8D8C-BA8F2A9962A8Q35676502-601B46F6-9602-4FD9-A087-6856ADCF8284Q35802323-5C597C65-1192-4BF5-AFA5-8666A8B89E8BQ36395803-30BB71D4-1F2E-42F2-A30B-2376030DCE6CQ36610752-476B9B1E-C0D4-4A04-BF67-7E7B27760830Q36616537-01832E4B-BDD8-425D-A305-18F0ACC87E62Q36641741-BCBA8027-427A-473B-99AC-2527B1A1F4ADQ36895793-2DCD3ADF-EAE0-4C46-BD7C-22D0AFEE00F2Q37005569-717148FA-FCFF-465E-84AA-3117EEF2B28DQ37091695-94A0E441-1F52-4F28-9800-E5A47BBD049CQ37163139-D547D814-FDA0-4D01-8DB2-5298E3990FBDQ37350801-D2672663-22EF-4EBA-A207-C05294269C4BQ37384736-20B7A8AC-3EDE-4311-96D1-64AC76B190B5Q37669484-290826A6-D89B-4B11-AF2C-98F92735EBB8Q37724199-84B44E79-637D-4CF3-B3A6-3C9263AC7CC3Q37750812-C2762554-86FF-4C48-B183-C63088EEE6EDQ37760957-DA24D5D0-F49E-4BDF-8328-DA4B2EFC7F2AQ37877701-BDC3399A-FAC2-4320-B831-D1E9AE00BC2AQ38255906-D05D6A0C-62CE-43B0-A781-667747C01850Q38280556-8A48DB83-456F-4D9C-B3FB-261E3178E885Q38309182-7728CB97-14D8-49CF-85BC-7D1514F9794EQ38611141-AD73E7AF-E9DE-45BA-9722-4ECD92D29079
P2860
Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove.
@ast
Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove.
@en
Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove.
@nl
type
label
Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove.
@ast
Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove.
@en
Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove.
@nl
prefLabel
Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove.
@ast
Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove.
@en
Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove.
@nl
P356
P1476
Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove.
@en
P2093
L H Hurley
M Zewail-Foote
P304
P356
10.1021/JM990241L
P407
P577
1999-07-01T00:00:00Z