Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction.
about
Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical ModelsThe interaction of lipophilic drugs with intestinal fatty acid-binding protein.Use of in vitro drug metabolism data to evaluate metabolic drug-drug interactions in man: the need for quantitative databases.Predictability of intranasal pharmacokinetics in man using pre-clinical pharmacokinetic data with a dopamine 3 receptor agonist, PF-219061.The metabolism of antihistamines and drug interactions: the role of cytochrome P450 enzymes.Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N-demethylation in human liver microsomes.Human drug metabolism and the cytochromes P450: application and relevance of in vitro models.Strategies to overcome simultaneous P-glycoprotein mediated efflux and CYP3A4 mediated metabolism of drugs.Lipid-based formulations for oral administration: opportunities for bioavailability enhancement and lipoprotein targeting of lipophilic drugs.The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism.Influence of dietary substances on intestinal drug metabolism and transport.Prediction of human pharmacokinetics--gut-wall metabolism.Evaluation of RNA-knockdown strategies for modulation of cytochrome P450 reductase activity in mouse hepatocytesSucralose, a synthetic organochlorine sweetener: overview of biological issuesReduced duodenal cytochrome P450 3A protein expression and catalytic activity in patients with cirrhosis.Efflux transporters- and cytochrome P-450-mediated interactions between drugs of abuse and antiretrovirals.Role of intestinal cytochrome P450 (P450) in modulating the bioavailability of oral lovastatin: insights from studies on the intestinal epithelium-specific P450 reductase knockout mouse.Pharmacokinetic strategies in deciphering atypical drug absorption profiles.Hepatic, gastric and intestinal first-pass effects of vitexin-2''-O-rhamnoside in rats by ultra-high-performance liquid chromatography.Pharmacokinetics of saquinavir, atazanavir, and ritonavir in a twice-daily boosted double-protease inhibitor regimenMechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport.Pharmacokinetics of tacrolimus during pregnancyPharmacokinetic Interactions between Drugs and Botanical Dietary Supplements.Dietary regulation of mouse intestinal P450 expression and drug metabolismPrediction of human pharmacokinetics--gastrointestinal absorption.Intestinal permeability and its relevance for absorption and elimination.The conduct of drug metabolism studies considered good practice (I): analytical systems and in vivo studiesAn intestinal epithelium-specific cytochrome P450 (P450) reductase-knockout mouse model: direct evidence for a role of intestinal p450s in first-pass clearance of oral nifedipine.Modeling kinetics of subcellular disposition of chemicals.Using molecular features of xenobiotics to predict hepatic gene expression responsePharmacogenomics of CYP3A: considerations for HIV treatment.Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination.Rapidly disintegrating oramucosal drug delivery technologies.Drug interactions between hormonal contraceptives and antiretrovirals.A review of multifunctional nanoemulsion systems to overcome oral and CNS drug delivery barriers.Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results.Loss of orally administered drugs in GI tract.In vitro-in vivo extrapolation (IVIVE) for predicting human intestinal absorption and first-pass elimination of drugs: principles and applications.Biomedical applications of microneedles in therapeutics: recent advancements and implications in drug delivery.Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.
P2860
Q26764739-61B0DA8A-1968-4F2E-B6B5-44C53F6F621FQ30983194-47014FF6-EAC4-4FC3-84E8-AB00E3DE519AQ31900846-F8B00102-2DB7-4896-8EDC-53E14B24A956Q33456110-0AFFA5F7-A483-4398-BB65-6DD824E93962Q33709784-FB2FB827-3A17-486F-8050-75DF091713EFQ34224925-4DFF7B23-C01C-429B-97EC-FEDD665D9E8CQ34430456-A7D0D9F5-26D4-47CF-BFAB-93F7C6C18C65Q34448305-3E117937-48BC-4F46-9A1A-93449AAE2C14Q34470793-97BD212D-DB20-4AA4-84BB-859642AAE162Q34479006-1036D0A7-412C-4115-AA06-AB3A2ADF312FQ34553835-991F0531-97B5-4CA1-8D9F-1B1421A4871FQ34583462-719B6786-4B99-4C5B-B342-9398B86F16F8Q34597021-675CFCF9-A266-4FBE-97A1-C450CE3E1DD4Q34657381-9445419F-0459-46D6-BB08-0E3A9A081435Q34659732-B2F00DFA-E6F5-426B-B57C-60A8CB22D58CQ35000765-1874A4EC-2C72-458E-AB14-D8CF0879D9C1Q35002429-13D94ED1-7BFF-4CE5-BDDC-2778CDEC9453Q35085676-8156FDDE-F5B0-4553-9BC6-1C38C6D9AF5DQ35648771-523F5114-DC88-42D2-B619-980339584C0AQ35758844-F62E263D-9F38-4E1E-84A4-15315FB08452Q36303746-7C38F1FF-262D-40EE-9688-72CBE547F042Q36400412-8E0803BD-B857-4EFE-8F39-1B754EFDE750Q36502919-D4DC2B4F-0ADC-4E78-AE76-8EDB461FAD47Q36573326-1F8420AB-1EE4-4845-A695-26DDD6F9AD75Q36885247-B2D2C5B0-F510-4551-B017-7147D810F3C6Q36985043-8F4771FC-DB0B-4FDD-8C45-0426824014ABQ37065418-28B08199-1E3D-4AE0-8772-8E849C162F84Q37104008-991E34DB-8531-484B-BDC6-A6EF5F5190F9Q37194304-0F6763BA-D4B4-450B-A938-6FD59E44774BQ37262219-614E12CA-C31D-4203-80BB-BFDBFAACE5E9Q37419542-3BF88096-3181-459F-A9AB-351E2199BBFCQ37600381-B67CBC38-BA2E-4E68-BA8F-B5A7992D9DB4Q37626036-700D86EB-42C6-452E-B217-49E8E825EF0FQ37735345-4E3C3F33-AFC9-4C8E-8441-76898378360CQ37798553-51A8D5BC-FCD3-440D-87A8-BCAD24377FFBQ38016204-242CDF9C-06DF-477A-B6E9-DC3A6E75A0B2Q38130231-FA1EA043-0089-4E78-AB2F-1E57CE1D1B3CQ38131859-8A285AB6-D391-4826-88A8-E08587978927Q38630763-C15F5557-0F36-4222-A0EC-421DB62ED502Q39805145-01EAFB7B-5EC4-41A9-862B-F96F6AF2C2DC
P2860
Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction.
description
1997 nî lūn-bûn
@nan
1997 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction.
@ast
Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction.
@en
Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction.
@nl
type
label
Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction.
@ast
Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction.
@en
Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction.
@nl
prefLabel
Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction.
@ast
Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction.
@en
Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction.
@nl
P2093
P1476
Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction.
@en
P2093
P304
P356
10.1016/S0169-409X(97)00039-2
P407
P577
1997-09-01T00:00:00Z