PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease. - Wikidata - wikimedia - TriplyDB

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease.

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease.

http://www.wikidata.org/entity/Q34509539

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Drug Repositioning for Alzheimer's Disease Based on Systematic 'omics' Data Mining Exploring the nexus of Alzheimer's disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer's Association & Alzheimer's Drug Discovery Foundation.Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer's Disease?Multifaceted interactions between adaptive immunity and the central nervous system.Immune Checkpoint in Glioblastoma: Promising and Challenging Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes.The retinal pigment epithelium as a gateway for monocyte trafficking into the eye.Molecular and genetic inflammation networks in major human diseases.The multi-target effects of CNI-1493: convergence of anti-amylodogenic and anti-inflammatory properties in animal models of Alzheimer's disease Are immune checkpoint blockade monoclonal antibodies active against CNS metastases from NSCLC?-current evidence and future perspectives.T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer's Disease: Potential Pools of New Biomarkers.Dissecting Amyloid Beta Deposition Using Distinct Strains of the Neurotropic Parasite Toxoplasma gondii as a Novel Tool.Inhibitors of programmed cell death 1 (PD-1): a patent review (2010-2015).Cytokine networks in neuroinflammation.Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice.Clearance of cerebral Aβ in Alzheimer's disease: reassessing the role of microglia and monocytes.Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy Microbial Immuno-Communication in Neurodegenerative Diseases Modulation of innate immunity of patients with Alzheimer's disease by omega-3 fatty acids.The roles of the PD-1/PD-L1 pathway at immunologically privileged sites.Amyloid beta: structure, biology and structure-based therapeutic development.Targeting neuroinflammation in Alzheimer's disease: evidence for NSAIDs and novel therapeutics.In situ and in silico kinetic analyses of programmed cell death-1 (PD-1) receptor, programmed cell death ligands, and B7-1 protein interaction network.Are We Moving Closer to Noninvasive Imaging and Monitoring of Neonatal Anesthesia-induced Neurotoxicity?Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease.Choroid plexus-cerebrospinal fluid route for monocyte-derived macrophages after stroke.Combination of Aβ Suppression and Innate Immune Activation in the Brain Significantly Attenuates Amyloid Plaque Deposition.Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia.Autoimmunity as a Driving Force of Cognitive Evolution.Etiogenic factors present in the cerebrospinal fluid from amyotrophic lateral sclerosis patients induce predominantly pro-inflammatory responses in microglia.Targeting Neuroinflammation to Treat Alzheimer's Disease.Glial Draper Rescues Aβ Toxicity in a Drosophila Model of Alzheimer's Disease.Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-β burden in several amyloid transgenic mouse models.Th17 cells in depression.Anti-PD-1/anti-CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8+ T cell trafficking.CNS side effects of immune checkpoint inhibitors: preclinical models, genetics and multimodality therapy.Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives.Can immunotherapy treat neurodegeneration?Central Regulation of Glucose Homeostasis.Neurodegenerative disease: Immunotherapy opportunity emerges for Alzheimer disease.

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PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease.

http://www.wikidata.org/entity/Q34509539

description

2016 nî lūn-bûn

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2016 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2016 թվականի հունվարին հրատարակված գիտական հոդված

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2016年の論文

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PD-1 immune checkpoint blockad ...... models of Alzheimer's disease.

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Nature Medicine

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PD-1 immune checkpoint blockad ...... models of Alzheimer's disease.

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Afroditi Tsitsou-Kampeli

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Alaa Mohammad Sharif

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Aleksandra Deczkowska

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Alexander Kertser

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Eyal David

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Ido Amit

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Kuti Baruch

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Michal Schwartz

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Neta Rosenzweig

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Orit Matcovitch-Natan

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P2860

Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

TopHat: discovering splice junctions with RNA-Seq

A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease

New immunotherapies targeting the PD-1 pathway

The blockade of immune checkpoints in cancer immunotherapy

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types.

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy.

Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology

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135-137

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10.1038/NM.4022

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Aleksandra Deczkowska

Orit Matcovitch-Natan

Afroditi Tsitsou-Kampeli

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2016-01-18T00:00:00Z

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291136003

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26779813

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Alzheimer's disease