Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
about
Metabolism leaves its mark on the powerhouse: recent progress in post-translational modifications of lysine in mitochondriaSIRT3 regulates progression and development of diseases of aging.Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4pMitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidationGeldanamycin-induced osteosarcoma cell death is associated with hyperacetylation and loss of mitochondrial pool of heat shock protein 60 (hsp60)Functional decorations: post-translational modifications and heart disease delineated by targeted proteomics.NAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents.Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity.In silico analysis of protein Lys-N(𝜀)-acetylation in plants.Understanding the acetylome: translating targeted proteomics into meaningful physiologyMitochondrial Lon protease at the crossroads of oxidative stress, ageing and cancer.The E. coli sirtuin CobB shows no preference for enzymatic and nonenzymatic lysine acetylation substrate sitesNutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation.Mitochondrial sirtuins and their relationships with metabolic disease and cancer.Lysine Acetylation Activates Mitochondrial Aconitase in the HeartUsing mitochondrial sirtuins as drug targets: disease implications and available compounds.SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target.Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions.Systematic Analysis of Mycobacterial Acylation Reveals First Example of Acylation-mediated Regulation of Enzyme Activity of a Bacterial PhosphataseHypoxia is associated with a lower expression of genes involved in lipogenesis in visceral adipose tissue.Mechanisms and Dynamics of Protein Acetylation in Mitochondria.NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice.Redox imbalance and mitochondrial abnormalities in the diabetic lung.Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory ChallengesNAD and ADP-ribose metabolism in mitochondria.An integrated perspective and functional impact of the mitochondrial acetylome.The growing landscape of lysine acetylation links metabolism and cell signalling.Role of CoA and acetyl-CoA in regulating cardiac fatty acid and glucose oxidation.Studies on the regulatory mechanism of isocitrate dehydrogenase 2 using acetylation mimics.Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation.Acetylation dynamics and stoichiometry in Saccharomyces cerevisiaePartial Immunoblotting of 2D-Gels: A Novel Method to Identify Post-Translationally Modified Proteins Exemplified for the Myelin Acetylome.Lysine-acetylation as a fundamental regulator of Ran function: Implications for signaling of proteins of the Ras-superfamily.SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic isletsObesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling.Site-specific reactivity of nonenzymatic lysine acetylation.The Arabidopsis class II sirtuin is a lysine deacetylase and interacts with mitochondrial energy metabolism.Mechanistic studies of malonic acid-mediated in situ acylation.A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function.
P2860
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P2860
Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
description
2012 nî lūn-bûn
@nan
2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Proteomic investigations of ly ...... tochondrial deacetylase sirt3.
@ast
Proteomic investigations of ly ...... tochondrial deacetylase sirt3.
@en
Proteomic investigations of ly ...... tochondrial deacetylase sirt3.
@nl
type
label
Proteomic investigations of ly ...... tochondrial deacetylase sirt3.
@ast
Proteomic investigations of ly ...... tochondrial deacetylase sirt3.
@en
Proteomic investigations of ly ...... tochondrial deacetylase sirt3.
@nl
prefLabel
Proteomic investigations of ly ...... tochondrial deacetylase sirt3.
@ast
Proteomic investigations of ly ...... tochondrial deacetylase sirt3.
@en
Proteomic investigations of ly ...... tochondrial deacetylase sirt3.
@nl
P2093
P2860
P1433
P1476
Proteomic investigations of ly ...... tochondrial deacetylase sirt3.
@en
P2093
Amit Kumar
Chu-Xia Deng
Chunaram Choudhary
Eri Maria Sol
Hyun-Seok Kim
Sebastian A Wagner
P2860
P304
P356
10.1371/JOURNAL.PONE.0050545
P407
P577
2012-12-07T00:00:00Z