Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS).
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Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical AppraisalPromiscuous Effects of Some Phenolic Natural Products on Inflammation at Least in Part Arise from Their Ability to Modulate the Expression of Global Regulators, Namely microRNAsThe emerging role of lysine methyltransferase SETD8 in human diseasesBIGCHEM: Challenges and Opportunities for Big Data Analysis in ChemistryEpigenetic assays for chemical biology and drug discovery.The Essential Medicinal Chemistry of CurcuminPotential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2.Phantom PAINS: Problems with the Utility of Alerts for Pan-Assay INterference CompoundS.Screening of the 'Open Scaffolds' collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes.Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.Histone acetyltransferase inhibitors: where art thou?Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ.ABCG2/BCRP: Specific and Nonspecific Modulators.Cellular analysis of the action of epigenetic drugs and probes.Non-kinase targets of protein kinase inhibitors.Exploring Anti-Prion Glyco-Based and Aromatic Scaffolds: A Chemical Strategy for the Quality of Life.From malaria to cancer: Computational drug repositioning of amodiaquine using PLIP interaction patterns.Anti-Influenza Virus Activity and Constituents. Characterization of Paeonia delavayi Extracts.Towards a systematic assessment of assay interference: Identification of extensively tested compounds with high assay promiscuity.Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B.Internal Structure and Preferential Protein Binding of Colloidal Aggregates.Naphthoquinones: A continuing source for discovery of therapeutic antineoplastic agents.Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors.Chemoinformatics: a perspective from an academic setting in Latin America.Actinorhodin is a redox-active antibiotic with a complex mode of action against Gram-positive cells.Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017-Utility and Limitations.Plant-derived antivirals against hepatitis c virus infection.A high-throughput screening campaign to identify inhibitors of DXP reductoisomerase (IspC) and MEP cytidylyltransferase (IspD).A Realistic View on "The Essential Medicinal Chemistry of Curcumin".Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry.Rce1: mechanism and inhibition.Cytoprotective Drug-Tissue Plasminogen Activator Protease Interaction Assays: Screening of Two Novel Cytoprotective Chromones.UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice.Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry.Biology must develop herd immunity against bad-actor molecules.In Silico Workflow for the Discovery of Natural Products Activating the G Protein-Coupled Bile Acid Receptor 1.The Ecstasy and Agony of Assay Interference CompoundsThe Ecstasy and Agony of Assay Interference CompoundsOpen chemoinformatic resources to explore the structure, properties and chemical space of moleculesFrom cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors
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Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS).
description
2016 nî lūn-bûn
@nan
2016 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Feeling Nature's PAINS: Natura ...... nterference Compounds (PAINS).
@ast
Feeling Nature's PAINS: Natura ...... nterference Compounds (PAINS).
@en
Feeling Nature's PAINS: Natura ...... nterference Compounds (PAINS).
@nl
type
label
Feeling Nature's PAINS: Natura ...... nterference Compounds (PAINS).
@ast
Feeling Nature's PAINS: Natura ...... nterference Compounds (PAINS).
@en
Feeling Nature's PAINS: Natura ...... nterference Compounds (PAINS).
@nl
prefLabel
Feeling Nature's PAINS: Natura ...... nterference Compounds (PAINS).
@ast
Feeling Nature's PAINS: Natura ...... nterference Compounds (PAINS).
@en
Feeling Nature's PAINS: Natura ...... nterference Compounds (PAINS).
@nl
P1476
Feeling Nature's PAINS: Natura ...... nterference Compounds (PAINS).
@en
P2093
Jonathan B Baell
P304
P356
10.1021/ACS.JNATPROD.5B00947
P577
2016-02-22T00:00:00Z