BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization.
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Synthetic lethality in lung cancer and translation to clinical therapiesFrom Proteomic Analysis to Potential Therapeutic Targets: Functional Profile of Two Lung Cancer Cell Lines, A549 and SW900, Widely Studied in Pre-Clinical ResearchSMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancersIntratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma.Collateral Lethality: A new therapeutic strategy in oncologySTAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation.ePIANNO: ePIgenomics ANNOtation tool.The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies.Brg1 Enables Rapid Growth of the Early Embryo by Suppressing Genes That Regulate Apoptosis and Cell Growth Arrest.Loss of switch/sucrose non-fermenting complex protein expression is associated with dedifferentiation in endometrial carcinomas.H4K5 histone acetylation of BRG1 is associated with heroin administration rather than addictionWidespread Chromatin Accessibility at Repetitive Elements Links Stem Cells with Human Cancer.The chromatin-remodeling enzyme BRG1 promotes colon cancer progression via positive regulation of WNT3A.Association of chromosome 19 to lung cancer genotypes and phenotypes.Epigenomic regulation of oncogenesis by chromatin remodeling.Modeling gene-wise dependencies improves the identification of drug response biomarkers in cancer studies.SMARCA4-deficient pulmonary adenocarcinoma: clinicopathological, immunohistochemical, and molecular characteristics of a novel aggressive neoplasm with a consistent TTF1(neg)/CK7(pos)/HepPar-1(pos) immunophenotype.TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin.Signatures of positive selection reveal a universal role of chromatin modifiers as cancer driver genes.Restoration of BRG1 inhibits proliferation and metastasis of lung cancer by regulating tumor suppressor miR-148b.Expanded molecular interrogation for potential actionable targets in non-squamous non-small cell lung cancer.SMARCA4 inactivation defines a group of undifferentiated thoracic malignancies transcriptionally related to BAF-deficient sarcomas.SCF-mediated degradation of Brg1 suppresses gastric cancer metastasis
P2860
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P2860
BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization.
description
2014 nî lūn-bûn
@nan
2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
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name
BRG1/SMARCA4 inactivation prom ...... tering chromatin organization.
@ast
BRG1/SMARCA4 inactivation prom ...... tering chromatin organization.
@en
BRG1/SMARCA4 inactivation prom ...... tering chromatin organization.
@nl
type
label
BRG1/SMARCA4 inactivation prom ...... tering chromatin organization.
@ast
BRG1/SMARCA4 inactivation prom ...... tering chromatin organization.
@en
BRG1/SMARCA4 inactivation prom ...... tering chromatin organization.
@nl
prefLabel
BRG1/SMARCA4 inactivation prom ...... tering chromatin organization.
@ast
BRG1/SMARCA4 inactivation prom ...... tering chromatin organization.
@en
BRG1/SMARCA4 inactivation prom ...... tering chromatin organization.
@nl
P2093
P2860
P1433
P1476
BRG1/SMARCA4 inactivation prom ...... ltering chromatin organization
@en
P2093
Austin Hepperla
Bernard Weissman
D Neil Hayes
Ian J Davis
Jeremy Simon
Joel Parker
Matthew D Wilkerson
Nisarg Desai
Shujie Song
Tess Orvis
P2860
P304
P356
10.1158/0008-5472.CAN-14-0061
P407
P577
2014-08-12T00:00:00Z