Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae
about
Streptococcus pneumoniae capsular serotype 19F is more resistant to C3 deposition and less sensitive to opsonophagocytosis than serotype 6BA Review of Pneumococcal Vaccines: Current Polysaccharide Vaccine Recommendations and Future Protein AntigensChanges in capsular serotype alter the surface exposure of pneumococcal adhesins and impact virulenceOverview of community-acquired pneumonia and the role of inflammatory mechanisms in the immunopathogenesis of severe pneumococcal disease.Role of complement in host defense against pneumococcal otitis mediaDiversity of pneumococcal surface protein A (PspA) among prevalent clones in SpainCombination of pneumococcal surface protein A (PspA) with whole cell pertussis vaccine increases protection against pneumococcal challenge in miceImmunization of mice with single PspA fragments induces antibodies capable of mediating complement deposition on different pneumococcal strains and cross-protection.A longitudinal study of natural antibody development to pneumococcal surface protein A families 1 and 2 in Papua New Guinean Highland children: a cohort studyInteraction of pneumococcal histidine triad proteins with human complement.Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production.Regulation of the pspA virulence factor and essential pcsB murein biosynthetic genes by the phosphorylated VicR (YycF) response regulator in Streptococcus pneumoniae.Human nasal challenge with Streptococcus pneumoniae is immunising in the absence of carriage.Involvement of potD in Streptococcus pneumoniae polyamine transport and pathogenesis.Correlation between in vitro complement deposition and passive mouse protection of anti-pneumococcal surface protein A monoclonal antibodies.Recruitment of complement factor H-like protein 1 promotes intracellular invasion by group A streptococci.Construction of otherwise isogenic serotype 6B, 7F, 14, and 19F capsular variants of Streptococcus pneumoniae strain TIGR4Relative roles of genetic background and variation in PspA in the ability of antibodies to PspA to protect against capsular type 3 and 4 strains of Streptococcus pneumoniaeTwo DHH subfamily 1 proteins contribute to pneumococcal virulence and confer protection against pneumococcal disease.Contributions of pneumolysin, pneumococcal surface protein A (PspA), and PspC to pathogenicity of Streptococcus pneumoniae D39 in a mouse model.Mucosal immunization with an unadjuvanted vaccine that targets Streptococcus pneumoniae PspA to human Fcγ receptor type I protects against pneumococcal infection through complement- and lactoferrin-mediated bactericidal activity.Cross-reactivity of antipneumococcal surface protein C (PspC) antibodies with different strains and evaluation of inhibition of human complement factor H and secretory IgA binding via PspC.Effects of PspA and antibodies to PspA on activation and deposition of complement on the pneumococcal surface.PspA and PspC minimize immune adherence and transfer of pneumococci from erythrocytes to macrophages through their effects on complement activation.Fusion proteins containing family 1 and family 2 PspA fragments elicit protection against Streptococcus pneumoniae that correlates with antibody-mediated enhancement of complement deposition.The absence of PspA or presence of antibody to PspA facilitates the complement-dependent phagocytosis of pneumococci in vitro.Pneumococcal surface protein A inhibits complement deposition on the pneumococcal surface by competing with the binding of C-reactive protein to cell-surface phosphocholinePneumococcal Surface Protein A Plays a Major Role in Streptococcus pneumoniae-Induced ImmunosuppressionConjugation of polysaccharide 6B from Streptococcus pneumoniae with pneumococcal surface protein A: PspA conformation and its effect on the immune responseDevelopment of antibodies to PspA families 1 and 2 in children after exposure to Streptococcus pneumoniaeSpecies-specific interaction of Streptococcus pneumoniae with human complement factor H.Novel Strategy To Protect against Influenza Virus-Induced Pneumococcal Disease without Interfering with Commensal ColonizationAnimal models of Streptococcus pneumoniae diseaseRationale and prospects for novel pneumococcal vaccines.Pneumococcal surface protein A contributes to secondary Streptococcus pneumoniae infection after influenza virus infection.Lipoprotein PsaA in virulence of Streptococcus pneumoniae: surface accessibility and role in protection from superoxide.Resistance of Mycoplasma pulmonis to complement lysis is dependent on the number of Vsa tandem repeats: shield hypothesis.Adhesion determinants of the Streptococcus species.The human polymeric immunoglobulin receptor binds to Streptococcus pneumoniae via domains 3 and 4.Streptococcus pneumoniae surface protein PcpA elicits protection against lung infection and fatal sepsis
P2860
Q24644461-AE9B8D96-B0F8-4FE1-856B-CDAA5B152098Q26753152-02EAC9AF-4D31-47F9-94A6-1D70892BD642Q28743699-E0D94F34-AC8D-4A24-8CCD-8E4C978BF405Q30358199-9B8386F0-19DB-4425-A3A9-C37971ADCE67Q33399371-830D926B-9950-455D-BDB9-3F24EC3DE952Q33439975-87E347E1-6AAB-4797-9A35-A35CD264935EQ33594345-D4C22FC3-CF58-47D8-B88A-A147E56DDA05Q33725192-67E3EE3A-0674-4667-A31A-4482508BA14CQ33802029-B2F6A73E-E853-494F-BFF1-E5A890FCD58DQ33826119-687C38D2-A7F3-4708-BB06-7F9E71AE5C22Q34103322-00B4D3E0-E7F1-4EB4-BB0F-FF9290D9B07BQ34110032-A5D6ADBE-8830-4FCE-A811-3D4FB2D0A23EQ34229627-145F4746-32D6-4D20-AD6B-B76BA7FE71B9Q34300938-3B1A09A3-CF74-4BB2-BC29-C1B086933107Q34784957-8F4BF997-6E6F-4F0C-81FC-5BC7DE44EF37Q34946557-97DC6CDA-6E5F-4B01-8A1B-D04F0013E9C9Q34998393-4AB2CD6D-2E18-490E-BC5B-2814425B2DEAQ35165275-4F62B5A4-D6C9-4F5D-84CF-BDFCC93C1410Q35191928-20BEC069-8A5D-46FA-9844-7BC67A60581AQ35783885-CD98E82F-61DD-46D1-9725-16939BB9C153Q35805480-D951BBA7-E900-4B6D-9CCD-EE9A3EFA178BQ35867202-DA6AB0CE-BB5A-492F-BEE8-BF5C03FDB7DEQ36228991-CC14AE8D-AA7C-4817-A684-DECE2BB5A972Q36313963-95B1ABBF-7FF1-4C11-B4CA-FF1F942FE9C7Q36314000-62998E40-7D96-497E-977D-FAD0A5D82592Q36362263-B030BFAA-B87D-49AF-8F90-320EE1AD7597Q36454995-CCAFFFAF-C4E7-4B41-A863-8A948BC08DFAQ36905498-FB6C2B40-83CA-4804-940C-F2F046181254Q36911270-24964D3A-6E26-481D-94CF-495F4DA37A41Q36933011-FDBF1EFD-1FDC-43B2-A3EE-473D98000822Q36984721-A3C2EF3B-9E66-4523-BA59-0146BF328D66Q37002290-8F0732FB-88B9-447C-AA48-5296DA31E676Q37293669-AE7BF14D-A93B-4F6D-B20D-826368A79408Q37309218-E98DB8B4-A884-4BE1-BFEF-C57FB8B4476EQ37328278-D9E9B0EE-09BB-4289-99A0-84DE879953AAQ37522871-B45F0DFA-38D1-4030-B502-EA8ADE06DD06Q37623816-C241DDDE-A129-430B-89B7-95ABA140FC38Q37831416-8A0F3A1C-1C2E-46E6-9B7B-DC895EDE006EQ38350313-78C66ECD-0409-45AE-BC9F-EBEC721D8FC4Q39023214-8963FD9E-FA6C-4ACD-9442-0BBAE70ADD97
P2860
Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Both family 1 and family 2 Psp ...... in of Streptococcus pneumoniae
@ast
Both family 1 and family 2 Psp ...... in of Streptococcus pneumoniae
@en
Both family 1 and family 2 Psp ...... in of Streptococcus pneumoniae
@nl
type
label
Both family 1 and family 2 Psp ...... in of Streptococcus pneumoniae
@ast
Both family 1 and family 2 Psp ...... in of Streptococcus pneumoniae
@en
Both family 1 and family 2 Psp ...... in of Streptococcus pneumoniae
@nl
prefLabel
Both family 1 and family 2 Psp ...... in of Streptococcus pneumoniae
@ast
Both family 1 and family 2 Psp ...... in of Streptococcus pneumoniae
@en
Both family 1 and family 2 Psp ...... in of Streptococcus pneumoniae
@nl
P2093
P2860
P1476
Both family 1 and family 2 Psp ...... in of Streptococcus pneumoniae
@en
P2093
David E Briles
Orlanda Thomas
Susan K Hollingshead
P2860
P356
10.1128/IAI.71.1.75-85.2003
P407
P577
2003-01-01T00:00:00Z