Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins - Wikidata - wikimedia - TriplyDB

Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins

Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins

http://www.wikidata.org/entity/Q34559507

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The emergence of acid ceramidase as a therapeutic target for acute myeloid leukemia.Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging.Glucose availability and glycolytic metabolism dictate glycosphingolipid levels Modulation of hepatitis C virus genome replication by glycosphingolipids and four-phosphate adaptor protein 2.Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets.Dissecting the in vivo leukemogenic potency of BCLxl.BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins.Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression Oncogenic properties of sphingosine kinases in haematological malignancies.Sphingolipids and mitochondrial apoptosis.Role of Sphingolipids and Metabolizing Enzymes in Hematological Malignancies.Increased ceramide production sensitizes breast cancer cell response to chemotherapy.Delivery systems of ceramide in targeted cancer therapy: ceramide alone or in combination with other anti-tumor agents.Runx1 Orchestrates Sphingolipid Metabolism and Glucocorticoid Resistance in Lymphomagenesis.SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models.IRAK1: oncotarget in MDS and AML.Acute Myeloid Leukemia: Is That All There Is?

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Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins

http://www.wikidata.org/entity/Q34559507

description

2013 nî lūn-bûn

@nan

2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2013 թվականի հունվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Inhibition of ceramide metabol ...... hibition of BCL2-like proteins

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Inhibition of ceramide metabol ...... hibition of BCL2-like proteins

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Inhibition of ceramide metabol ...... hibition of BCL2-like proteins

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type

label

Inhibition of ceramide metabol ...... hibition of BCL2-like proteins

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Inhibition of ceramide metabol ...... hibition of BCL2-like proteins

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Inhibition of ceramide metabol ...... hibition of BCL2-like proteins

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prefLabel

Inhibition of ceramide metabol ...... hibition of BCL2-like proteins

@ast

Inhibition of ceramide metabol ...... hibition of BCL2-like proteins

@en

Inhibition of ceramide metabol ...... hibition of BCL2-like proteins

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JOURNAL.PONE.0054525

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Inhibition of ceramide metabol ...... hibition of BCL2-like proteins

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Craig Thomas

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Jonathan M Keller

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Lauren Howell

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Lavona Casson

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Leah J Siskind

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Lesley A Mathews

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Levi J Beverly

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Marc Ferrer

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Rajarshi Guha

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P2860

The Hallmarks of Cancer

Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations

Principles of bioactive lipid signalling: lessons from sphingolipids

Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

The Bcl-2 protein family: arbiters of cell survival

Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells.

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e54525

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scholarly article

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10.1371/JOURNAL.PONE.0054525

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