Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template. - Wikidata - wikimedia - TriplyDB

Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template.

Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template.

http://www.wikidata.org/entity/Q34559611

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Optimising homing endonuclease gene drive performance in a semi-refractory species: the Drosophila melanogaster experience In Vivo Delivery Systems for Therapeutic Genome Editing Homing endonucleases: DNA scissors on a mission Tapping natural reservoirs of homing endonucleases for targeted gene modification Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects Performance of the Cas9 nickase system in Drosophila melanogaster.Fanconi anemia gene editing by the CRISPR/Cas9 system.To nick or not to nick: comparison of I-SceI single- and double-strand break-induced recombination in yeast and human cells.Zinc-finger nucleases for somatic gene therapy: the next frontier.Homing endonucleases: from genetic anomalies to programmable genomic clippers Efficient Genome Editing in Clostridium cellulolyticum via CRISPR-Cas9 Nickase.Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors.Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold.Tracking genome engineering outcome at individual DNA breakpoints Homologous recombination rescues ssDNA gaps generated by nucleotide excision repair and reduced translesion DNA synthesis in yeast G2 cells.Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects.Homing endonucleases: from microbial genetic invaders to reagents for targeted DNA modification.Towards artificial metallonucleases for gene therapy: recent advances and new perspectives.Molecular scissors for in situ cellular repair.Targeted gene therapies: tools, applications, optimization Emerging gene editing strategies for Duchenne muscular dystrophy targeting stem cells.Precision genome editing: a small revolution for glycobiology."Breaking news" from spermatids.High-Throughput Silencing Using the CRISPR-Cas9 System: A Review of the Benefits and Challenges.Sequence-specific DNA nicking endonucleases.Distinct genetic control of homologous recombination repair of Cas9-induced double-strand breaks, nicks and paired nicks.The democratization of gene editing: Insights from site-specific cleavage and double-strand break repair.CRISPR-based genome editing and expression control systems in Clostridium acetobutylicum and Clostridium beijerinckii.Genome editing: a robust technology for human stem cells.Adeno-associated virus inverted terminal repeats stimulate gene editing Concerted nicking of donor and chromosomal acceptor DNA promotes homology-directed gene targeting in human cells.Site- and strand-specific nicking of DNA by fusion proteins derived from MutH and I-SceI or TALE repeats Compact designer TALENs for efficient genome engineering.Efficient CRISPR-Cas9-mediated generation of knockin human pluripotent stem cells lacking undesired mutations at the targeted locus.Natural zinc ribbon HNH endonucleases and engineered zinc finger nicking endonuclease.In trans paired nicking triggers seamless genome editing without double-stranded DNA cutting.PARP-mediated repair, homologous recombination, and back-up non-homologous end joining-like repair of single-strand nicks Precise genome-wide base editing by the CRISPR Nickase system in yeast A novel zinc-finger nuclease platform with a sequence-specific cleavage module.

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Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template.

http://www.wikidata.org/entity/Q34559611

description

2010 nî lūn-bûn

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2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年論文

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Single-strand nicks induce hom ...... using an AAV vector template.

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Single-strand nicks induce hom ...... using an AAV vector template.

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Single-strand nicks induce hom ...... using an AAV vector template.

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Single-strand nicks induce hom ...... using an AAV vector template.

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Single-strand nicks induce hom ...... using an AAV vector template.

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Single-strand nicks induce hom ...... using an AAV vector template.

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Single-strand nicks induce hom ...... using an AAV vector template.

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Single-strand nicks induce hom ...... using an AAV vector template.

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A Dusty Miller

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Audrey McConnell-Smith

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Barry L Stoddard

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Michael J Metzger

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P2860

Alternative induction of meiotic recombination from single-base lesions of DNA deaminases

Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

DNA binding and cleavage by the HNH homing endonuclease I-HmuI

The structure of E. coli beta-galactosidase.

Site-specific integration of adeno-associated virus involves partial duplication of the target locus.

Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes.

Biochemical characterization of adeno-associated virus rep68 DNA helicase and ATPase activities.

Human gene targeting favors insertions over deletions.

Group I intron homing in Bacillus phages SPO1 and SP82: a gene conversion event initiated by a nicking homing endonuclease.

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10.1093/NAR/GKQ826

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