The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.
about
Preclinical animal anxiety research - flaws and prejudices.Structure, function, and modulation of GABA(A) receptorsPharmacological Properties of DOV 315,090, an ocinaplon metabolite.Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia.Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats?Anxiolytic-like effects of mitragynine in the open-field and elevated plus-maze tests in rats.2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors.Contribution of alpha1 subunit-containing gamma-aminobutyric acidA (GABAA) receptors to motor-impairing effects of benzodiazepines in squirrel monkeysAltered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome.Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects.The 5-HT6 receptor agonist EMD 386088 produces antidepressant and anxiolytic effects in rats after intrahippocampal administration.
P2860
Q26749038-A4532689-DAFE-45F0-9DE7-292E5B3E14C0Q26859328-62A93B09-D69C-429B-9535-CBF973858CF0Q33343725-551C2795-D577-455F-B0C9-B32ECA2FF7EDQ33714843-AA1793A3-FA15-4F46-B776-A2EF7ECD3119Q33810376-E628A004-F652-4FB4-B1E9-D272D3BC8BC8Q34400172-2B2B25D2-7AD2-4A2B-A63B-7D5FE57D1C0DQ35853220-7A1308B8-4932-4016-859C-8898327F6296Q37132185-00555B73-ED1E-4F92-BB2B-C8C8404DCF3FQ37175224-1179522E-9E19-49AF-AF3C-1EF67A38C932Q37718608-49CD11D3-29F0-4DBC-9CB4-B35A57FC0879Q42597841-A44EB3B5-4BA6-489D-BBC7-0D6D0C4ABC94
P2860
The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
@ast
The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
@en
The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
@nl
type
label
The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
@ast
The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
@en
The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
@nl
prefLabel
The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
@ast
The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
@en
The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
@nl
P2093
P50
P356
P1476
The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
@en
P2093
Anthony S Basile
Arnold S Lippa
Emmanuel Kostakis
Phil Skolnick
Philip Krieter
Zhengming Chen
P304
P356
10.1124/JPET.106.107201
P407
P50
P577
2006-09-13T00:00:00Z