Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A.
about
Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo.Cytochrome P450 2J2: distribution, function, regulation, genetic polymorphisms and clinical significance.Ebastine in the light of CONGA recommendations for the development of third-generation antihistaminesImmunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine.Unusual regioselectivity and active site topology of human cytochrome P450 2J2Roles of the epoxygenase CYP2J2 in the endothelium.Functional studies of N-terminally modified CYP2J2 epoxygenase in model lipid bilayersCYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems.Activity, inhibition, and induction of cytochrome P450 2J2 in adult human primary cardiomyocytes.Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2.Functional characterization of drug uptake and metabolism in the heart.Myocardial pharmacokinetics of ebastine, a substrate for cytochrome P450 2J, in rat isolated heart.Editor's Highlight: Transgenic Zebrafish Reporter Lines as Alternative In Vivo Organ Toxicity Models.Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase.Itraconazole and rifampin alter significantly the disposition and antihistamine effect of ebastine and its metabolites in healthy participants.A Critical Review of Physicochemical Properties and Analytical Methods Applied to Quantitative Determination of Ebastine.Computational modelling of the binding of arachidonic acid to the human monooxygenase CYP2J2.Heme Modification Contributes to the Mechanism-Based Inactivation of Human Cytochrome P450 2J2 by Two Terminal Acetylenic Compounds.In vitro characterization of 4'-(p-toluenesulfonylamide)-4-hydroxychalcone using human liver microsomes and recombinant cytochrome P450s.Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2
P2860
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P2860
Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A.
description
2006 nî lūn-bûn
@nan
2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Characterization of ebastine, ...... or roles for CYP2J2 and CYP3A.
@ast
Characterization of ebastine, ...... or roles for CYP2J2 and CYP3A.
@en
Characterization of ebastine, ...... or roles for CYP2J2 and CYP3A.
@nl
type
label
Characterization of ebastine, ...... or roles for CYP2J2 and CYP3A.
@ast
Characterization of ebastine, ...... or roles for CYP2J2 and CYP3A.
@en
Characterization of ebastine, ...... or roles for CYP2J2 and CYP3A.
@nl
prefLabel
Characterization of ebastine, ...... or roles for CYP2J2 and CYP3A.
@ast
Characterization of ebastine, ...... or roles for CYP2J2 and CYP3A.
@en
Characterization of ebastine, ...... or roles for CYP2J2 and CYP3A.
@nl
P2093
P356
P1476
Characterization of ebastine, ...... or roles for CYP2J2 and CYP3A.
@en
P2093
Chang Soo Choi
Dong-Jun Lee
Jae-Gook Shin
Ji-Hong Shon
Kwang-Hyeon Liu
Mi-Gyung Kim
Min-Jung Kim
Young Kil Choi
Yune-Jung Yoon
Zeuresenay Desta
P304
P356
10.1124/DMD.106.010488
P577
2006-08-08T00:00:00Z