PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors.
about
Emerging concepts in the immunopathogenesis of AIDSRole of PD-1 in HIV pathogenesis and as target for therapyEnhancing Human Immunodeficiency Virus-Specific CD8(+) T Cell Responses with Heteroclitic PeptidesCD8 T cell persistence in treated HIV infectionHigh Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical OutcomeA dimeric structure of PD-L1: functional units or evolutionary relics?PD-L1 Blockade Differentially Impacts Regulatory T Cells from HIV-Infected Individuals Depending on Plasma ViremiaAntigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cellsHIV-1 Vaccine Trials: Evolving Concepts and DesignsChronically inflamed livers up-regulate expression of inhibitory B7 family members.PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice.Effective simian immunodeficiency virus-specific CD8+ T cells lack an easily detectable, shared characteristic.Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustionNatural course of chronic hepatitis B is characterized by changing patterns of programmed death type-1 of CD8-positive T cells.Proliferation capacity and cytotoxic activity are mediated by functionally and phenotypically distinct virus-specific CD8 T cells defined by interleukin-7R{alpha} (CD127) and perforin expression.Immune dysregulation in human immunodeficiency virus infection: know it, fix it, prevent it?Early skewed distribution of total and HIV-specific CD8+ T-cell memory phenotypes during primary HIV infection is related to reduced antiviral activity and faster disease progressionPhenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsets.Immunity to HIV in Early LifeCD4 T-cell help programs a change in CD8 T-cell function enabling effective long-term control of murine gammaherpesvirus 68: role of PD-1-PD-L1 interactions.Polymorphisms in toll-like receptor 4 and toll-like receptor 9 influence viral load in a seroincident cohort of HIV-1-infected individualsPartial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway.Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load.Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infectionLymphocyte activation gene-3 expression defines a discrete subset of HIV-specific CD8+ T cells that is associated with lower viral loadProgrammed death-1 expression on CD4⁺ and CD8⁺ T cells in treated and untreated HIV disease.Blockade of the programmed death-1 pathway restores sarcoidosis CD4(+) T-cell proliferative capacity.Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic optionsCell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivoSoluble PD-1 rescues the proliferative response of simian immunodeficiency virus-specific CD4 and CD8 T cells during chronic infection.Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infectionSevere functional impairment and elevated PD-1 expression in CD1d-restricted NKT cells retained during chronic HIV-1 infectionImmunopathogenesis of asymptomatic chronic HIV Infection: the calm before the storm.Therapeutic immunization in HIV infected Ugandans receiving stable antiretroviral treatment: a Phase I safety studyImpaired CD8(+) T cell immunity after allogeneic bone marrow transplantation leads to persistent and severe respiratory viral infection.Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease.Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.Dendritic cell control of tolerogenic responses.Safety and immunological responses to human mesenchymal stem cell therapy in difficult-to-treat HIV-1-infected patients.
P2860
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P2860
PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors.
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
PD-1 up-regulation is correlat ...... t in long-term nonprogressors.
@ast
PD-1 up-regulation is correlat ...... t in long-term nonprogressors.
@en
PD-1 up-regulation is correlat ...... t in long-term nonprogressors.
@nl
type
label
PD-1 up-regulation is correlat ...... t in long-term nonprogressors.
@ast
PD-1 up-regulation is correlat ...... t in long-term nonprogressors.
@en
PD-1 up-regulation is correlat ...... t in long-term nonprogressors.
@nl
prefLabel
PD-1 up-regulation is correlat ...... t in long-term nonprogressors.
@ast
PD-1 up-regulation is correlat ...... t in long-term nonprogressors.
@en
PD-1 up-regulation is correlat ...... t in long-term nonprogressors.
@nl
P2093
P1433
P1476
PD-1 up-regulation is correlat ...... t in long-term nonprogressors.
@en
P2093
Fu-Sheng Wang
Ji-Yuan Zhang
Jianan Wei
Jinxia Yao
Jun-Liang Fu
Liangen Chen
P304
P356
10.1182/BLOOD-2006-09-044826
P407
P577
2007-02-01T00:00:00Z