The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.

The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.

Item
http://www.wikidata.org/entity/Q34580395
In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I MetabolitesZNF32 inhibits autophagy through the mTOR pathway and protects MCF-7 cells from stimulus-induced cell death.The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.Targeting cancer by binding iron: Dissecting cellular signaling pathwaysA novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIα.Induction of MAPK- and ROS-dependent autophagy and apoptosis in gastric carcinoma by combination of romidepsin and bortezomibThe novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms.The iron chelator Dp44mT suppresses osteosarcoma's proliferation, invasion and migration: in vitro and in vivoTargeting autophagy in antitumor agent design: furthering the 'lysosomal love' strategy.Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.Combination of Fe/Cu -chelators and docosahexaenoic acid: an exploration for the treatment of colorectal cancer.IRON METABOLISM AND AUTOPHAGY: A POORLY EXPLORED RELATIONSHIP THAT HAS IMPORTANT CONSEQUENCES FOR HEALTH AND DISEASE.Therapeutic Strategies against Epstein-Barr Virus-Associated Cancers Using Proteasome Inhibitors.
P2860

The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.

Item
http://www.wikidata.org/entity/Q34580395
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2014 nî lūn-bûn
@nan
2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
The anticancer agent di-2-pyri ...... irment of lysosomal integrity.
@ast
The anticancer agent di-2-pyri ...... irment of lysosomal integrity.
@en
The anticancer agent di-2-pyri ...... irment of lysosomal integrity.
@nl
type
label
The anticancer agent di-2-pyri ...... irment of lysosomal integrity.
@ast
The anticancer agent di-2-pyri ...... irment of lysosomal integrity.
@en
The anticancer agent di-2-pyri ...... irment of lysosomal integrity.
@nl
prefLabel
The anticancer agent di-2-pyri ...... irment of lysosomal integrity.
@ast
The anticancer agent di-2-pyri ...... irment of lysosomal integrity.
@en
The anticancer agent di-2-pyri ...... irment of lysosomal integrity.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932
P356
P1433
P1476
The anticancer agent di-2-pyri ...... airment of lysosomal integrity
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932