Shared active sites in oligomeric enzymes: model studies with defective mutants of aspartate transcarbamoylase produced by site-directed mutagenesis.
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Structure and critical residues at the active site of spermidine/spermine-N1-acetyltransferaseReplacement of Asp-162 by Ala prevents the cooperative transition by the substrates while enhancing the effect of the allosteric activator ATP on E. coli aspartate transcarbamoylaseHuman argininosuccinate lyase: a structural basis for intragenic complementationArginine 54 in the active site of escherichia coli aspartate transcarbamoylase is critical for catalysis: A site-specific mutagenesis, NMR, and X-ray crystallographic studyActive-site-directed inactivation of wheat-germ aspartate transcarbamoylase by pyridoxal 5'-phosphateTime Evolution of the Quaternary Structure of Escherichia coli Aspartate Transcarbamoylase upon Reaction with the Natural Substrates and a Slow, Tight-Binding InhibitorSubunit functional studies of NAD(P)H:quinone oxidoreductase with a heterodimer approach.A tetramer of the Flp recombinase silences the trimers within it during resolution of a Holliday junction substrate.Posttranslational oligomerization and cooperative acid activation of mixed influenza hemagglutinin trimers.Weakening of the interface between adjacent catalytic chains promotes domain closure in Escherichia coli aspartate transcarbamoylaseStructural similarity between ornithine and aspartate transcarbamoylases of Escherichia coli: characterization of the active site and evidence for an interdomain carboxy-terminal helix in ornithine transcarbamoylase.The 80s loop of the catalytic chain of Escherichia coli aspartate transcarbamoylase is critical for catalysis and homotropic cooperativityThe use of nucleotide analogs to evaluate the mechanism of the heterotropic response of Escherichia coli aspartate transcarbamoylase.The dual-mode quaternary structure of seminal RNaseMolecular and cellular regulation of autotrophic carbon dioxide fixation in microorganisms.Patient selection may affect gene therapy success. Dominant negative effects observed for ornithine transcarbamylase in mouse and human hepatocytes.A 70-amino acid zinc-binding polypeptide from the regulatory chain of aspartate transcarbamoylase forms a stable complex with the catalytic subunit leading to markedly altered enzyme activityThe biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review.Mechanisms of cooperativity and allosteric regulation in proteins.Protein engineering. The design, synthesis and characterization of factitious proteins.Dimer formation by a "monomeric" protein.Subunit complementation of Escherichia coli adenylosuccinate synthetase.Complementation analysis of mutants of 1-aminocyclopropane- 1-carboxylate synthase reveals the enzyme is a dimer with shared active sites.Acidic residues important for substrate binding and cofactor reactivity in eukaryotic ornithine decarboxylase identified by alanine scanning mutagenesis.Function of Escherichia coli biotin carboxylase requires catalytic activity of both subunits of the homodimer.Characterization of a monomeric Escherichia coli alkaline phosphatase formed upon a single amino acid substitution.Disruption of a salt bridge dramatically accelerates subunit exchange in duck delta2 crystallin.Aspartate Transcarbamylase from Escherichia Coli: Activity and Regulation
P2860
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P2860
Shared active sites in oligomeric enzymes: model studies with defective mutants of aspartate transcarbamoylase produced by site-directed mutagenesis.
description
1987 nî lūn-bûn
@nan
1987 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
name
Shared active sites in oligome ...... by site-directed mutagenesis.
@ast
Shared active sites in oligome ...... by site-directed mutagenesis.
@en
Shared active sites in oligome ...... by site-directed mutagenesis.
@nl
type
label
Shared active sites in oligome ...... by site-directed mutagenesis.
@ast
Shared active sites in oligome ...... by site-directed mutagenesis.
@en
Shared active sites in oligome ...... by site-directed mutagenesis.
@nl
prefLabel
Shared active sites in oligome ...... by site-directed mutagenesis.
@ast
Shared active sites in oligome ...... by site-directed mutagenesis.
@en
Shared active sites in oligome ...... by site-directed mutagenesis.
@nl
P2860
P356
P1476
Shared active sites in oligome ...... by site-directed mutagenesis.
@en
P2093
H K Schachman
P2860
P356
10.1073/PNAS.84.1.31
P407
P577
1987-01-01T00:00:00Z