Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. - Wikidata - wikimedia - TriplyDB

Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin.

Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin.

http://www.wikidata.org/entity/Q34584029

about

Molecular cloning and characterization of a novel histone deacetylase HDAC10 Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates.Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer Histone deacetylases (HDACs): characterization of the classical HDAC family Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition Macrocyclic histone deacetylase inhibitors Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun.Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption Small molecule inhibitors of zinc-dependent histone deacetylases Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1 SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth 2-Benzazolyl-4-Piperazin-1-Ylsulfonylbenzenecarbohydroxamic Acids as Novel Selective Histone Deacetylase-6 Inhibitors with Antiproliferative Activity Histone deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity.In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index.Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.Induction of human gamma globin gene expression by histone deacetylase inhibitors TLR ligands, but not modulators of histone modifiers, can induce the complex immune response pattern of endotoxin tolerance in mammary epithelial cells.Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils.Modularity and directionality in genetic interaction maps.Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases.Chromosomal integration of retinoic acid response elements prevents cooperative transcriptional activation by retinoic acid receptor and retinoid X receptor.Probing the bioactive conformation of an archetypal natural product HDAC inhibitor with conformationally homogeneous triazole-modified cyclic tetrapeptides.Design and synthesis of novel hybrid benzamide-peptide histone deacetylase inhibitors Chemical genetic approaches to probing cell death.Dietary manipulation of histone structure and function.Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors.Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention.Epigenetic therapy for breast cancer.Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents.A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells.On the inhibition of histone deacetylase 8 Ectopic hbox12 Expression Evoked by Histone Deacetylase Inhibition Disrupts Axial Specification of the Sea Urchin Embryo

P2860

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P2860

Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin.

http://www.wikidata.org/entity/Q34584029

description

2001 nî lūn-bûn

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2001 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի հունվարին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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name

Potent histone deacetylase inh ...... ntibiotics including trapoxin.

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Potent histone deacetylase inh ...... ntibiotics including trapoxin.

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Potent histone deacetylase inh ...... ntibiotics including trapoxin.

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type

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Potent histone deacetylase inh ...... ntibiotics including trapoxin.

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Potent histone deacetylase inh ...... ntibiotics including trapoxin.

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Potent histone deacetylase inh ...... ntibiotics including trapoxin.

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Potent histone deacetylase inh ...... ntibiotics including trapoxin.

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P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Potent histone deacetylase inh ...... ntibiotics including trapoxin.

@en

P2093

Furumai R

http://www.w3.org/2001/XMLSchema#string

Horinouchi S

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Khochbin S

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Komatsu Y

http://www.w3.org/2001/XMLSchema#string

Nishino N

http://www.w3.org/2001/XMLSchema#string

Yoshida M

http://www.w3.org/2001/XMLSchema#string

P2860

Three proteins define a class of human histone deacetylases related to yeast Hda1p

mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity

Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

HDAC4 deacetylase associates with and represses the MEF2 transcription factor

HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor

Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression

Characterization of a human RPD3 ortholog, HDAC3

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

P304

87-92

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scholarly article

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10.1073/PNAS.011405598

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P433

1

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P478

98

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24446635

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11134513

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P932

14549

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