Molecular engineering approaches to peptide, polyketide and other antibiotics.
about
Bioprospecting Sponge-Associated Microbes for Antimicrobial CompoundsSynthetic biology of antimicrobial discoveryThe sulfur atoms of the substrate CoA and the catalytic cysteine are required for a productive mode of substrate binding in bacterial biosynthetic thiolase, a thioester-dependent enzymeIn vitro characterization of the anti-bacterial activity of SQ109 against Helicobacter pyloriEnzymatic fine-tuning for 2-(6-hydroxynaphthyl) β-D-xylopyranoside synthesis catalyzed by the recombinant β-xylosidase BxTW1 from Talaromyces amestolkiaeDirected evolution can rapidly improve the activity of chimeric assembly-line enzymes.Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner.Ribosomal synthesis of N-methyl peptides.In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites.Cloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clustersGenetically engineered lipopeptide antibiotics related to A54145 and daptomycin with improved properties.Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?Metabolic engineering for the production of natural products.Discovery research: the scientific challenge of finding new antibiotics.SBSPKS: structure based sequence analysis of polyketide synthasesRecombinatorial biosynthesis of polyketides.The complex extracellular biology of Streptomyces.Tools for metabolic engineering in StreptomycesToward improvement of erythromycin A production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombination.Engineered polyketide biosynthesis and biocatalysis in Escherichia coli.Direct cloning, genetic engineering, and heterologous expression of the syringolin biosynthetic gene cluster in E. coli through Red/ET recombineering.Mapping the limits of substrate specificity of the adenylation domain of TycA.Diversity and biotechnological potential of microorganisms associated with marine sponges.Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentationIdentification and biotechnological application of novel regulatory genes involved in Streptomyces polyketide overproduction through reverse engineering strategy."Head-to-side-chain" cyclodepsipeptides of marine origin.Functional characterization and substrate specificity of spinosyn rhamnosyltransferase by in vitro reconstitution of spinosyn biosynthetic enzymesThe structural diversity of acidic lipopeptide antibiotics.Biotechnology of polyketides: new breath of life for the novel antibiotic genetic pathways discovery through metagenomicsPKS and NRPS release mechanisms.Natural products and synthetic biologySynthetic biology of secondary metabolite biosynthesis in actinomycetes: Engineering precursor supply as a way to optimize antibiotic production.Anaerobic bacteria as producers of antibiotics.Mining the cinnabaramide biosynthetic pathway to generate novel proteasome inhibitors.A molecular key for building hyphae aggregates: the role of the newly identified Streptomyces protein HyaS.Conformational changes in the novel redox sensor protein HbpS studied by site-directed spin labeling and its turnover in dependence on the catalase-peroxidase CpeB.Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivo.Fatty Acyl Incorporation in the Biosynthesis of WAP-8294A, a Group of Potent Anti-MRSA Cyclic Lipodepsipeptides.Development of a genetic system for combinatorial biosynthesis of lipopeptides in Streptomyces fradiae and heterologous expression of the A54145 biosynthesis gene cluster.Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides.
P2860
Q26752805-AAD7F69B-29A9-4323-BFF9-428928E2B006Q27001264-9C9A024B-9055-4D68-BE4B-01F469F0FBA1Q27652926-0511DECE-2655-4E9F-B7B8-CFDCB93022E5Q28534899-D59F3D6B-8F74-4603-B021-20CF8EF9B404Q28822514-D65FB74D-630C-41CA-B370-70ED8C300455Q33290356-1E6191B0-9C03-46AF-B154-FCD715147E6DQ33304966-1B35E1D5-618B-4E6C-A013-E1DCCC447C4FQ33327536-085BAD6E-A185-4A5D-BDF7-EA9EC9367D39Q33379284-986A3A93-7B37-4098-94B7-D3DCFAD71B23Q33530183-5845AA0E-DE64-4739-A4A6-4859256724D6Q33768851-791BB61B-5AD1-4776-8B72-1ED72DF692A5Q33804081-53CC7E78-2A17-480F-9ADE-654AA1250B48Q33829836-7A862D62-A5F5-425E-B2CF-35BEEDCF6C76Q33941796-B9CA2ABE-ABB6-4119-BAA5-DEF6323F36D3Q33957606-491B4077-4644-4046-84DD-A48C8575B9CAQ34063381-31004356-1AED-460D-9525-4CDF3EBAD89DQ34093836-05F023A3-796C-46A4-B31E-F7463DD2A371Q34142945-98A050B6-C785-4BFA-9C41-8FAF18DE8908Q34207948-FE5DDD01-5388-465F-8946-37C0B2036C6BQ34311936-9034E627-2927-4312-ACF9-516811E8C405Q34360740-B0096248-C211-4615-BD6B-43071252577BQ34935927-0B4CFB7D-8FBD-44D2-BA62-6FD5F4359604Q35203338-E294244B-46D6-45BD-B6DD-294A4C5A09A5Q36497775-1A99F38B-2916-4F66-93F7-1963474ED725Q36702895-BEADB375-A57F-4087-9C0A-D10E24F04ECBQ36999172-58EFB499-D867-4161-9079-7AAFE91524C8Q37119844-C6294B06-1CAE-4E71-9B26-9C4D47314F47Q37373526-9C6E7F3C-7615-413D-B361-27F4282A955FQ37644182-EBCFB6E2-28D7-42B1-9407-D48E871C2391Q37683524-3AFFC043-5E8C-424A-8BE4-3010FB9B758EQ37711590-9D8430E1-E8AA-4B2E-BCC4-754FCF8C5BE9Q38019704-A82C9221-ACEC-4586-BF22-D7974EA17C71Q38031395-449A0DE7-217D-4FB7-91CF-89EBA7044550Q39579038-321D32C8-E7B6-45B4-B63B-D7EA65E760EBQ39983959-6AABE537-3AC1-4225-82D8-920053B6B4CAQ41051762-7708F215-06ED-42B0-BF78-6DB115C4F100Q41482513-E4742C15-76D3-4CEC-B887-AE022E40A141Q41529106-97B6E312-A85B-45D5-A879-CE3D7B36300BQ42411102-86961281-57BF-439C-B6B0-E7AFDDD25DF4Q48299636-D52B978D-D214-48F9-B517-E7F5E297B1D7
P2860
Molecular engineering approaches to peptide, polyketide and other antibiotics.
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Molecular engineering approaches to peptide, polyketide and other antibiotics.
@ast
Molecular engineering approaches to peptide, polyketide and other antibiotics.
@en
Molecular engineering approaches to peptide, polyketide and other antibiotics.
@nl
type
label
Molecular engineering approaches to peptide, polyketide and other antibiotics.
@ast
Molecular engineering approaches to peptide, polyketide and other antibiotics.
@en
Molecular engineering approaches to peptide, polyketide and other antibiotics.
@nl
prefLabel
Molecular engineering approaches to peptide, polyketide and other antibiotics.
@ast
Molecular engineering approaches to peptide, polyketide and other antibiotics.
@en
Molecular engineering approaches to peptide, polyketide and other antibiotics.
@nl
P356
P1433
P1476
Molecular engineering approaches to peptide, polyketide and other antibiotics.
@en
P2093
Richard H Baltz
P2888
P304
P356
10.1038/NBT1265
P577
2006-12-01T00:00:00Z