ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function.

ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function.

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http://www.wikidata.org/entity/Q34591124
Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3.ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice.ApoE4 induces synaptic and ERG impairments in the retina of young targeted replacement apoE4 miceAPOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice.Apolipoprotein E, amyloid-ß clearance and therapeutic opportunities in Alzheimer's diseaseDevelopment of new fusion proteins for visualizing amyloid-β oligomers in vivoBlocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degenerationCognitive deficits and disruption of neurogenesis in a mouse model of apolipoprotein E4 domain interactionIncreased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer's disease pathogenesis.Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo.
P2860

ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function.

Item
http://www.wikidata.org/entity/Q34591124
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
ApoE4-Driven Accumulation of I ...... ediated by a Gain of Function.
@en
ApoE4-Driven Accumulation of I ...... ediated by a Gain of Function.
@nl
type
label
ApoE4-Driven Accumulation of I ...... ediated by a Gain of Function.
@en
ApoE4-Driven Accumulation of I ...... ediated by a Gain of Function.
@nl
prefLabel
ApoE4-Driven Accumulation of I ...... ediated by a Gain of Function.
@en
ApoE4-Driven Accumulation of I ...... ediated by a Gain of Function.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
ApoE4-Driven Accumulation of I ...... ediated by a Gain of Function.
@en
P2093
P2860
P304
P31
P356
P478
P50
P577
P5875
P698
P932