Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene.
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Neonatal Fc receptor mediates internalization of Fc in transfected human endothelial cellsFc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeuticsRapid and reversible responses to IVIG in autoimmune neuromuscular diseases suggest mechanisms of action involving competition with functionally important autoantibodiesUnraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based TherapeuticsThe neonatal Fc receptor, FcRn, as a target for drug delivery and therapyThe recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity.Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn.Distribution of candidate genes for experimentally induced arthritis in ratsHepatic FcRn regulates albumin homeostasis and susceptibility to liver injuryRediscovering Beta-2 Microglobulin As a Biomarker across the Spectrum of Kidney Diseases.Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor.Neonatal Fc receptor: from immunity to therapeuticsThe fate and function of therapeutic antiaddiction monoclonal antibodies across the reproductive cycle of rats.Clinical ramifications of the MHC family Fc receptor FcRn.FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin.Analysis of Response Elements Involved in the Regulation of the Human Neonatal Fc Receptor Gene (FCGRT).Decoding the Structural Bases of D76N ß2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis.Improved tumor imaging and therapy via i.v. IgG-mediated time-sequential modulation of neonatal Fc receptor.Discovery and fine mapping of serum protein loci through transethnic meta-analysisHow the controller is controlled - neonatal Fc receptor expression and immunoglobulin G homeostasis.The Implication and Significance of Beta 2 Microglobulin: A Conservative Multifunctional Regulator.Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy.Immunoglobulin replacement therapy in children.An inactivated cell culture Japanese encephalitis vaccine (JE-ADVAX) formulated with delta inulin adjuvant provides robust heterologous protection against West Nile encephalitis via cross-protective memory B cells and neutralizing antibodyFcRn in the yolk sac endoderm of mouse is required for IgG transport to fetusImmune and non-immune functions of the (not so) neonatal Fc receptor, FcRn.Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn.Mapping of the neonatal Fc receptor in the rodent eye.Pharmacokinetics, pharmacodynamics and physiologically-based pharmacokinetic modelling of monoclonal antibodies.Receptor-mediated endocytosis and brain delivery of therapeutic biologics.ADME of monoclonal antibody biotherapeutics: knowledge gaps and emerging tools.Albumin and its application in drug delivery.Different brands of intravenous immunoglobulin for primary immunodeficiencies: how to choose the best option for the patient?The multiple facets of FcRn in immunity.Cell surface dynamics and cellular distribution of endogenous FcRn.Gestation age dependent transfer of human immunoglobulins across placenta in timed-pregnant guinea pigs.Potential Sources of Inter-Subject Variability in Monoclonal Antibody Pharmacokinetics.Incorporation of FcRn-mediated disposition model to describe the population pharmacokinetics of therapeutic monoclonal IgG antibody in clinical patients.Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding.Functional polymorphisms in rhesus macaque FCGRT and β2-m.
P2860
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P2860
Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene.
description
2006 nî lūn-bûn
@nan
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Familial hypercatabolic hypopr ...... tant beta2-microglobulin gene.
@ast
Familial hypercatabolic hypopr ...... tant beta2-microglobulin gene.
@en
Familial hypercatabolic hypopr ...... tant beta2-microglobulin gene.
@nl
type
label
Familial hypercatabolic hypopr ...... tant beta2-microglobulin gene.
@ast
Familial hypercatabolic hypopr ...... tant beta2-microglobulin gene.
@en
Familial hypercatabolic hypopr ...... tant beta2-microglobulin gene.
@nl
prefLabel
Familial hypercatabolic hypopr ...... tant beta2-microglobulin gene.
@ast
Familial hypercatabolic hypopr ...... tant beta2-microglobulin gene.
@en
Familial hypercatabolic hypopr ...... tant beta2-microglobulin gene.
@nl
P2093
P2860
P356
P1476
Familial hypercatabolic hypopr ...... tant beta2-microglobulin gene.
@en
P2093
C L Bronson
Chaity Chaudhury
Clark L Anderson
John M Robinson
Jonghan Kim
Lynn D Haynes
Manzoor A Wani
Sudhasri Mohanty
Thomas A Waldmann
P2860
P304
P356
10.1073/PNAS.0600548103
P407
P577
2006-03-20T00:00:00Z