Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene. - Wikidata - wikimedia - TriplyDB

Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene.

Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene.

http://www.wikidata.org/entity/Q34596901

about

Neonatal Fc receptor mediates internalization of Fc in transfected human endothelial cells Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics Rapid and reversible responses to IVIG in autoimmune neuromuscular diseases suggest mechanisms of action involving competition with functionally important autoantibodies Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity.Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn.Distribution of candidate genes for experimentally induced arthritis in rats Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury Rediscovering Beta-2 Microglobulin As a Biomarker across the Spectrum of Kidney Diseases.Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor.Neonatal Fc receptor: from immunity to therapeutics The fate and function of therapeutic antiaddiction monoclonal antibodies across the reproductive cycle of rats.Clinical ramifications of the MHC family Fc receptor FcRn.FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin.Analysis of Response Elements Involved in the Regulation of the Human Neonatal Fc Receptor Gene (FCGRT).Decoding the Structural Bases of D76N ß2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis.Improved tumor imaging and therapy via i.v. IgG-mediated time-sequential modulation of neonatal Fc receptor.Discovery and fine mapping of serum protein loci through transethnic meta-analysis How the controller is controlled - neonatal Fc receptor expression and immunoglobulin G homeostasis.The Implication and Significance of Beta 2 Microglobulin: A Conservative Multifunctional Regulator.Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy.Immunoglobulin replacement therapy in children.An inactivated cell culture Japanese encephalitis vaccine (JE-ADVAX) formulated with delta inulin adjuvant provides robust heterologous protection against West Nile encephalitis via cross-protective memory B cells and neutralizing antibody FcRn in the yolk sac endoderm of mouse is required for IgG transport to fetus Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn.Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn.Mapping of the neonatal Fc receptor in the rodent eye.Pharmacokinetics, pharmacodynamics and physiologically-based pharmacokinetic modelling of monoclonal antibodies.Receptor-mediated endocytosis and brain delivery of therapeutic biologics.ADME of monoclonal antibody biotherapeutics: knowledge gaps and emerging tools.Albumin and its application in drug delivery.Different brands of intravenous immunoglobulin for primary immunodeficiencies: how to choose the best option for the patient?The multiple facets of FcRn in immunity.Cell surface dynamics and cellular distribution of endogenous FcRn.Gestation age dependent transfer of human immunoglobulins across placenta in timed-pregnant guinea pigs.Potential Sources of Inter-Subject Variability in Monoclonal Antibody Pharmacokinetics.Incorporation of FcRn-mediated disposition model to describe the population pharmacokinetics of therapeutic monoclonal IgG antibody in clinical patients.Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding.Functional polymorphisms in rhesus macaque FCGRT and β2-m.

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Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene.

http://www.wikidata.org/entity/Q34596901

description

2006 nî lūn-bûn

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2006 թուականի Մարտին հրատարակուած գիտական յօդուած

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2006 թվականի մարտին հրատարակված գիտական հոդված

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2006年の論文

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Familial hypercatabolic hypopr ...... tant beta2-microglobulin gene.

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Familial hypercatabolic hypopr ...... tant beta2-microglobulin gene.

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Proceedings of the National Academy of Sciences of the United States of America

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Familial hypercatabolic hypopr ...... tant beta2-microglobulin gene.

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C L Bronson

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Chaity Chaudhury

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Clark L Anderson

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John M Robinson

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Jonghan Kim

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Lynn D Haynes

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Manzoor A Wani

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Sudhasri Mohanty

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Thomas A Waldmann

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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.

A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus

The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan

An Fc receptor structurally related to MHC class I antigens

Hinges, swivels and switches: the role of prolines in signalling via transmembrane alpha-helices.

beta(2)-Microglobulin is important for cell surface expression and pH-dependent IgG binding of human FcRn.

Isolation from human placenta of the IgG transporter, FcRn, and localization to the syncytiotrophoblast: implications for maternal-fetal antibody transport.

Beta 2-microglobulin gene mutations: a study of established colorectal cell lines and fresh tumors

Familial hypercatabolic hypoproteinemia. A disorder of endogenous catabolism of albumin and immunoglobulin.

The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor

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