Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. - Wikidata - wikimedia - TriplyDB

Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.

Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.

http://www.wikidata.org/entity/Q34597362

about

The N-end rule pathway Discovery of cellular regulation by protein degradation Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1 Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system Glutamine-specific N-terminal amidase, a component of the N-end rule pathway Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination The substrate recognition domains of the N-end rule pathway.The UBR-box and its relationship to binuclear RING-like treble clef zinc fingers Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease.The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway.Ubiquitin ligases of the N-end rule pathway: assessment of mutations in UBR1 that cause the Johanson-Blizzard syndrome A neurostimulant para-chloroamphetamine inhibits the arginylation branch of the N-end rule pathway.The N-end rule pathway and regulation by proteolysis Profiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis.Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila.Expression and biochemical characterization of the human enzyme N-terminal asparagine amidohydrolase.Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.Whole brain expression of bipolar disorder associated genes: structural and genetic analyses UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition.Cardiac Nav 1.5 is modulated by ubiquitin protein ligase E3 component n-recognin UBR3 and 6.Pharmacological Modulation of the N-End Rule Pathway and Its Therapeutic Implications.Listeriolysin O secreted by Listeria monocytogenes into the host cell cytosol is degraded by the N-end rule pathway.Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7 UBE2B is implicated in myofibrillar protein loss in catabolic C2C12 myotubes.Transgenic rescue of ataxia mice reveals a male-specific sterility defect.Multivalency-assisted control of intracellular signaling pathways: application for ubiquitin- dependent N-end rule pathway.Inability to fully suppress sterol synthesis rates with exogenous sterol in embryonic and extraembyronic fetal tissues Protein Quality Control by Molecular Chaperones in Neurodegeneration.Role of the ubiquitin-proteasome system in nervous system function and disease: using C. elegans as a dissecting tool.p600/UBR4 in the central nervous system.The role of taurine in improving neural stem cells proliferation and differentiation.Physiological functions and clinical implications of the N-end rule pathway.The antiapoptotic activity of insect IAPs requires activation by an evolutionarily conserved mechanism.Analyzing N-terminal Arginylation through the Use of Peptide Arrays and Degradation Assays.The arginylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearance of proteotoxic proteins.Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway.The C-terminal proteolytic fragment of the breast cancer susceptibility type 1 protein (BRCA1) is degraded by the N-end rule pathway.

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P2860

Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.

http://www.wikidata.org/entity/Q34597362

description

2006 nî lūn-bûn

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2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2006 թվականի ապրիլին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.

@ast

Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.

@en

Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.

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type

label

Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.

@ast

Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.

@en

Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.

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prefLabel

Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.

@ast

Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.

@en

Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.

@nl

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PNAS.0601700103

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Impaired neurogenesis and card ...... UBR2 of the N-end rule pathway

@en

P2093

Alexander Varshavsky

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Jai Wha Seo

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Jee Young An

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Takafumi Tasaki

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Yong Tae Kwon

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P2860

Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway

A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.

The N-end rule: functions, mysteries, uses

Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway

The mouse and human genes encoding the recognition component of the N-end rule pathway

CDK inhibitors: positive and negative regulators of G1-phase progression

Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway.

Yeast N-terminal amidase. A new enzyme and component of the N-end rule pathway.

Back to the future with ubiquitin

Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes

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103

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Aparato circulatorio

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1458857

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