"Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening
about
Computational approaches to natural product discoveryIdentification of the First Marine-Derived Opioid Receptor "Balanced" Agonist with a Signaling Profile That Resembles the EndorphinsIntegration of high-content screening and untargeted metabolomics for comprehensive functional annotation of natural product librariesMechanism of action-based classification of antibiotics using high-content bacterial image analysis.Anti-cancer agents in Saudi Arabian herbals revealed by automated high-content imaging.Large-scale cytological profiling for functional analysis of bioactive compounds.Discovery and biological characterization of the auromomycin chromophore as an inhibitor of biofilm formation in Vibrio cholerae.Identification of a molecular target of a novel fungal metabolite, pyrrolizilactone, by phenotypic profiling systems.The Natural Product N-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human SpliceosomesMatching the power of high throughput screening to the chemical diversity of natural productsTools for characterizing bacterial protein synthesis inhibitors.Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs.Image-based 384-well high-throughput screening method for the discovery of skyllamycins A to C as biofilm inhibitors and inducers of biofilm detachment in Pseudomonas aeruginosa.An NF-κB-based high-throughput screen identifies piericidins as inhibitors of the Yersinia pseudotuberculosis type III secretion system.Bioactive Potential of Marine Macroalgae from the Central Red Sea (Saudi Arabia) Assessed by High-Throughput Imaging-Based Phenotypic Profiling.Data-analysis strategies for image-based cell profiling.Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase.Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites.Mining prokaryotes for antimicrobial compounds: from diversity to function.Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae.Optimized quinoline amino alcohols as disruptors and dispersal agents of Vibrio cholerae biofilms.High-resolution phenotypic profiling of natural products-induced effects on the single-cell level.Integrated metabolomics approach facilitates discovery of an unpredicted natural product suite from Streptomyces coelicolor M145.The contribution of mechanistic understanding to phenotypic screening for first-in-class medicines.Machine learning and image-based profiling in drug discovery
P2860
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P2860
"Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening
description
2013 nî lūn-bûn
@nan
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
"Function-first" lead discover ...... es using image-based screening
@ast
"Function-first" lead discover ...... es using image-based screening
@en
"Function-first" lead discover ...... es using image-based screening
@nl
type
label
"Function-first" lead discover ...... es using image-based screening
@ast
"Function-first" lead discover ...... es using image-based screening
@en
"Function-first" lead discover ...... es using image-based screening
@nl
prefLabel
"Function-first" lead discover ...... es using image-based screening
@ast
"Function-first" lead discover ...... es using image-based screening
@en
"Function-first" lead discover ...... es using image-based screening
@nl
P2093
P2860
P1476
"Function-first" lead discover ...... es using image-based screening
@en
P2093
Christopher J Schulze
Joshua Stuart
Marcos H Woerhmann
R Scott Lokey
Walter M Bray
P2860
P304
P356
10.1016/J.CHEMBIOL.2012.12.007
P577
2013-02-01T00:00:00Z