Functional overlap in mismatch repair by human MSH3 and MSH6. - Wikidata - wikimedia - TriplyDB

Functional overlap in mismatch repair by human MSH3 and MSH6.

Functional overlap in mismatch repair by human MSH3 and MSH6.

http://www.wikidata.org/entity/Q34603929

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MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility DNA replication fidelity and cancer Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2 Rate, molecular spectrum, and consequences of human mutation Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant glioma Cooperative nuclear localization sequences lend a novel role to the N-terminal region of MSH6.Genetic analysis of mouse embryonic stem cells bearing Msh3 and Msh2 single and compound mutations Both hMutSα and hMutSß DNA mismatch repair complexes participate in 5-fluorouracil cytotoxicity.In vivo and in vitro studies of immunoglobulin gene somatic hypermutation.Msh6 protects mature B cells from lymphoma by preserving genomic stability.Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells.MSH3-deficiency initiates EMAST without oncogenic transformation of human colon epithelial cells.Characterization of the repeat-tract instability and mutator phenotypes conferred by a Tn3 insertion in RFC1, the large subunit of the yeast clamp loader Regulation of mitotic homeologous recombination in yeast. Functions of mismatch repair and nucleotide excision repair genes.Frequent germline mutations and somatic repeat instability in DNA mismatch-repair-deficient Caenorhabditis elegans Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis.The lower bound to the evolution of mutation rates.Mononucleotide microsatellite instability and germline MSH6 mutation analysis in early onset colorectal cancer Correction of the UDP-glucuronosyltransferase gene defect in the gunn rat model of crigler-najjar syndrome type I with a chimeric oligonucleotide The Changes in MGMT Promoter Methylation Status in Initial and Recurrent Glioblastomas Mismatch repair hMSH2, hMLH1, hMSH6 and hPMS2 mRNA expression profiles in precancerous and cancerous urothelium A personal historical view of DNA mismatch repair with an emphasis on eukaryotic DNA mismatch repair.Functional analysis of the mismatch repair system in bladder cancer.Modeling the Etiology of p53-mutated Cancer Cells.Regulation of the human MSH6 gene by the Sp1 transcription factor and alteration of promoter activity and expression by polymorphisms.Mutation rates, spectra, and genome-wide distribution of spontaneous mutations in mismatch repair deficient yeast.Mismatch repair protein deficiency compromises cisplatin-induced apoptotic signaling.Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture).Mismatch repair gene MSH3 polymorphism is associated with the risk of sporadic prostate cancer.Generation of a mouse mutant by oligonucleotide-mediated gene modification in ES cells.Acidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity.Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part I. The utility of immunohistochemistry.MutSbeta exceeds MutSalpha in dinucleotide loop repair.Production of truncated MBD4 protein by frameshift mutation in DNA mismatch repair-deficient cells enhances 5-fluorouracil sensitivity that is independent of hMLH1 status.Germline and somatic mutation analysis of MLH3 in MSI-positive colorectal cancer.MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia.Targeted next generation sequencing identified clinically actionable mutations in patients with esophageal sarcomatoid carcinoma.

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Functional overlap in mismatch repair by human MSH3 and MSH6.

http://www.wikidata.org/entity/Q34603929

description

1998 nî lūn-bûn

@nan

1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի ապրիլին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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name

Functional overlap in mismatch repair by human MSH3 and MSH6.

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Functional overlap in mismatch repair by human MSH3 and MSH6.

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Functional overlap in mismatch repair by human MSH3 and MSH6.

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type

label

Functional overlap in mismatch repair by human MSH3 and MSH6.

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Functional overlap in mismatch repair by human MSH3 and MSH6.

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Functional overlap in mismatch repair by human MSH3 and MSH6.

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Functional overlap in mismatch repair by human MSH3 and MSH6.

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Functional overlap in mismatch repair by human MSH3 and MSH6.

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Functional overlap in mismatch repair by human MSH3 and MSH6.

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Functional overlap in mismatch repair by human MSH3 and MSH6

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A Umar

http://www.w3.org/2001/XMLSchema#string

J C Barrett

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J I Risinger

http://www.w3.org/2001/XMLSchema#string

K R Tindall

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T A Kunkel

http://www.w3.org/2001/XMLSchema#string

W E Glaab

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P2860

Purified human MSH2 protein binds to DNA containing mismatched nucleotides

The Saccharomyces cerevisiae Msh2 and Msh6 proteins form a complex that specifically binds to duplex oligonucleotides containing mismatched DNA base pairs.

Genetic and biochemical analysis of Msh2p-Msh6p: role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition.

Enhancement of MSH2-MSH3-mediated mismatch recognition by the yeast MLH1-PMS1 complex.

Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3.

Binding of mismatched microsatellite DNA sequences by the human MSH2 protein

Biochemistry and genetics of eukaryotic mismatch repair

Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells

GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells

Mutations of GTBP in genetically unstable cells

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