Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis. - Wikidata - wikimedia - TriplyDB

Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis.

Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis.

http://www.wikidata.org/entity/Q34607187

about

Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446 Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction The formation and function of ER-endosome membrane contact sites EGF receptor trafficking: consequences for signaling and cancer Targeting Inactive Enzyme Conformation: Aryl Diketoacid Derivatives as a New Class of PTP1B Inhibitors Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis Protein tyrosine phosphatase PTPN13 negatively regulates Her2/ErbB2 malignant signaling.Genomic-wide analysis of lymphatic metastasis-associated genes in human hepatocellular carcinoma.Insufficient milk supply and breast cancer risk: a systematic review.Targeting PTPs with small molecule inhibitors in cancer treatment Discovery of novel PTP1B inhibitors with antihyperglycemic activity.Protein tyrosine phosphatase 1B expression contributes to the development of breast cancer.Kinetics and mechanism of protein tyrosine phosphatase 1B inactivation by acrolein.ACSL1 Is Associated With Fetal Programming of Insulin Sensitivity and Cellular Lipid Content Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice.Targeting the disordered C terminus of PTP1B with an allosteric inhibitor Substrate specificity of protein tyrosine phosphatases 1B, RPTPα, SHP-1, and SHP-2.Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells.Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFNγ signaling.Protein tyrosine phosphatase 1B inhibitors: a molecular level legitimate approach for the management of diabetes mellitus.Protein tyrosine phosphatases as potential therapeutic targets.PTP1B suppresses prolactin activation of Stat5 in breast cancer cells.Protein tyrosine phosphatase 4A2 expression predicts overall and disease-free survival of human breast cancer and is associated with estrogen and progestin receptor status.The epidermal growth factor receptor family: biology driving targeted therapeutics.Critical role of Shp2 in tumor growth involving regulation of c-Myc Targeting protein tyrosine phosphatases for anticancer drug discovery.Protein Tyrosine Phosphatase 1B (PTP1B) deficiency accelerates hepatic regeneration in mice A new highly efficient substrate-trapping mutant of protein tyrosine phosphatase 1B (PTP1B) reveals full autoactivation of the insulin receptor precursor.Missing-in-Metastasis regulates cell motility and invasion via PTPδ-mediated changes in SRC activity.A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells.Inactivation of protein tyrosine phosphatases by oltipraz and other cancer chemopreventive 1,2-dithiole-3-thiones.Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells.ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis.Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma.

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P2860

Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis.

http://www.wikidata.org/entity/Q34607187

description

2007 nî lūn-bûn

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2007 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2007 թվականի հունվարին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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Protein tyrosine phosphatase 1 ...... protects from lung metastasis.

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Protein tyrosine phosphatase 1 ...... protects from lung metastasis.

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Protein tyrosine phosphatase 1 ...... protects from lung metastasis.

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Protein tyrosine phosphatase 1 ...... protects from lung metastasis.

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Protein tyrosine phosphatase 1 ...... protects from lung metastasis.

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Protein tyrosine phosphatase 1 ...... protects from lung metastasis.

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Protein tyrosine phosphatase 1 ...... protects from lung metastasis.

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Protein tyrosine phosphatase 1 ...... protects from lung metastasis.

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Protein tyrosine phosphatase 1 ...... protects from lung metastasis.

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Nature Genetics

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Protein tyrosine phosphatase 1 ...... protects from lung metastasis.

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P2093

Brian P Kennedy

http://www.w3.org/2001/XMLSchema#string

Janice Penney

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Marilene Paquet

http://www.w3.org/2001/XMLSchema#string

Michel L Tremblay

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Michelle Read

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Nadia Dubé

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Sofi G Julien

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William J Muller

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Yongxin Han

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P2860

Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines

A quantitative protein interaction network for the ErbB receptors using protein microarrays

Src family kinases in tumor progression and metastasis

Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand

The role of protein tyrosine phosphatase 1B in Ras signaling

Essential function for ErbB3 in breast cancer proliferation

The deaf and the dumb: the biology of ErbB-2 and ErbB-3

Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

P2888

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338-346

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10.1038/NG1963

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3

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39

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2007-01-28T00:00:00Z

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6544128

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17259984

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