Genotypic stability, segregation and selection in heteroplasmic human cell lines containing np 3243 mutant mtDNA. - Wikidata - wikimedia - TriplyDB

Genotypic stability, segregation and selection in heteroplasmic human cell lines containing np 3243 mutant mtDNA.

Genotypic stability, segregation and selection in heteroplasmic human cell lines containing np 3243 mutant mtDNA.

http://www.wikidata.org/entity/Q34608474

about

Composition and dynamics of human mitochondrial nucleoids A wide range of 3243A>G/tRNALeu(UUR) (MELAS) mutation loads may segregate in offspring through the female germline bottleneck.The road to rack and ruin: selecting deleterious mitochondrial DNA variants Transmission of mitochondrial DNA diseases and ways to prevent them.Non-random mtDNA segregation patterns indicate a metastable heteroplasmic segregation unit in m.3243A>G cybrid cells.Reactive oxygen species stimulate mitochondrial allele segregation toward homoplasmy in human cells.Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells.Single-cell A3243G mitochondrial DNA mutation load assays for segregation analysis Systematic segregation to mutant mitochondrial DNA and accompanying loss of mitochondrial DNA in human NT2 teratocarcinoma Cybrids.Pervasive within-Mitochondrion Single-Nucleotide Variant Heteroplasmy as Revealed by Single-Mitochondrion Sequencing.Resolving the Enigma of the Clonal Expansion of mtDNA Deletions.

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Genotypic stability, segregation and selection in heteroplasmic human cell lines containing np 3243 mutant mtDNA.

http://www.wikidata.org/entity/Q34608474

description

2000 nî lūn-bûn

@nan

2000 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի հունվարին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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Genotypic stability, segregati ...... ntaining np 3243 mutant mtDNA.

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Genotypic stability, segregati ...... ntaining np 3243 mutant mtDNA.

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Genotypic stability, segregati ...... ntaining np 3243 mutant mtDNA.

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P2860

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Cofilin is a component of intranuclear and cytoplasmic actin rods induced in cultured cells.

Homopolymeric tract heteroplasmy in mtDNA from tissues and single oocytes: support for a genetic bottleneck.

An update on the mitochondrial-DNA mutation hypothesis of cell aging.

Rolling circle replication of DNA in yeast mitochondria

Human mitochondria and mitochondrial genome function as a single dynamic cellular unit.

Complementation of mutant and wild-type human mitochondrial DNAs coexisting since the mutation event and lack of complementation of DNAs introduced separately into a cell within distinct organelles.

Defects in mitochondrial protein synthesis and respiratory chain activity segregate with the tRNA(Leu(UUR)) mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes.

MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts.

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