Human hepatocytes: isolation, cryopreservation and applications in drug development.
about
Is There a Space-Based Technology Solution to Problems with Preclinical Drug Toxicity Testing?Evaluation of Adverse Drug Properties with Cryopreserved Human Hepatocytes and the Integrated Discrete Multiple Organ Co-culture (IdMOC(TM)) SystemEvaluation of database-derived pathway development for enabling biomarker discovery for hepatotoxicityBiobanking for research in surgery: are surgeons in charge for advancing translational research or mere assistants in biomaterial and data preservation?Prediction of hepatic clearance in human from in vitro data for successful drug development.Combined use of N-acetylcysteine and Liberase improves the viability and metabolic function of human hepatocytes isolated from human liverIntegrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System.Isolation of primary human hepatocytes from normal and diseased liver tissue: a one hundred liver experienceBis(hydroxyphenyl)methane-bisphenol F-metabolism by the HepG2 human hepatoma cell line and cryopreserved human hepatocytes.Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity.In vitro, in vivo and in silico metabolic profiling of α-pyrrolidinopentiothiophenone, a novel thiophene stimulant."Universal" vitrification of cells by ultra-fast cooling.Drug activity screening based on microsomes-hydrogel system in predicting metabolism induced antitumor effect of oroxylin AApplicability of the Rayleigh equation for enantioselective metabolism of chiral xenobiotics by microsomes, hepatocytes and in-vivo retention in rabbit tissues.Scalable Differentiation of Human iPSCs in a Multicellular Spheroid-based 3D Culture into Hepatocyte-like Cells through Direct Wnt/β-catenin Pathway Inhibition.Microscale diffusion measurements and simulation of a scaffold with a permeable strutPotential herb-drug interaction of shexiang baoxin pill in vitro based on drug metabolism/transporterLong-term virus-induced alterations of CYP3A-mediated drug metabolism: a look at the virology, immunology and molecular biology of a multi-faceted problem.Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines.Therapeutic hepatocyte transplant for inherited metabolic disorders: functional considerations, recent outcomes and future prospects.An evaluation of the latest in vitro tools for drug metabolism studies.Biomarkers and human hepatocytes.Cytochrome P450 time-dependent inhibition and induction: advances in assays, risk analysis and modelling.Scientific concepts and applications of integrated discrete multiple organ co-culture technology.Development of novel tools for the in vitro investigation of drug-induced liver injury.A Review of the Application of Body-on-a-Chip for Drug Test and Its Latest Trend of Incorporating Barrier Tissue.Liver Cell Culture Devices.Evaluating the Effects of Dithiothreitol and Fructose on Cell Viability and Function of Cryopreserved Primary Rat Hepatocytes and HepG2 Cell Line.Equine hepatocytes: isolation, cryopreservation, and applications to in vitro drug metabolism studies.First metabolic profile of PV8, a novel synthetic cathinone, in human hepatocytes and urine by high-resolution mass spectrometry.In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease.Cold Preservation of Human Adult Hepatocytes for Liver Cell Therapy.Generation of proliferating human hepatocytes using Upcyte® technology: characterisation and applications in induction and cytotoxicity assays.Hepatocyte CYP2B6 Can Be Expressed in Cell Culture Systems by Exerting Physiological Levels of Shear: Implications for ADME TestingAssessment of cytochrome P450 (1A2, 2B6, 2C9 and 3A4) induction in cryopreserved human hepatocytes cultured in 48-well plates using the cocktail strategy.Comparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes.Wheat proteins enhance stability and function of adhesion molecules in cryopreserved hepatocytes.Assessment of cryopreserved human hepatocytes as a model system to investigate sulfation and glucuronidation and to evaluate inhibitors of drug conjugation.Absorption, distribution, metabolism and excretion of novel phosphodiesterase type 4 inhibitor ASP3258 in rats.Primary human hepatocytes on biodegradable poly(l-lactic acid) matrices: a promising model for improving transplantation efficiency with tissue engineering.
P2860
Q26749381-76C9A69E-7503-422C-8868-0E9170E891ACQ26801904-FF2329B2-F10D-484D-AB83-AF8D71D92E60Q27027301-5CA4861C-FCE8-40E0-B343-3D613B953A4EQ30592366-55D2A956-702B-4C95-9E55-1A5969829925Q33437736-4BAD39A7-DD74-4D15-B0FC-17D3EF1B370DQ33642195-2CBA58A6-FD08-4DA9-AF8E-74B67F902627Q33792887-74590169-9721-4E3C-A1A4-EAC5D66D3A12Q33867498-901281BE-EBD9-4108-8F53-2486D2CCFD46Q34201779-92D8A72C-BD03-4F5F-903C-BFB8280495DBQ34330504-79D4D55E-0316-45E5-BE79-96A9D1AD1152Q34504512-EB550655-B26A-42DF-970A-0386D0D85669Q35500444-43CB3404-7FAF-418E-99F1-615396F769E5Q36610906-EEBB42D0-5DA8-4409-96D7-BA13BCBB30CBQ36735906-2A83F4A4-E071-4C39-8328-4AC68659DE62Q37247461-9D8118CE-9BFC-485C-ACB4-7BAD78B50D0EQ37291247-E89CEF28-D6A9-4838-AA67-6083D11BEF78Q37553816-D985B1EF-467A-465B-9371-C0DFF252FDB3Q37592262-BD6884EE-027C-436C-8E29-3A2969C3D022Q37604385-1CB40391-19EE-409C-987F-38EB227BE35BQ37684677-381A188A-70CF-4EBD-A2AB-5DE320C1EF7DQ38160881-D2578518-7670-4341-A889-EC652B9AEC4BQ38187449-422C1298-86ED-485F-8979-69B4BEC45BDCQ38346846-FD597321-867C-46B3-8768-EE0558E27EDBQ38476999-C1246213-1E58-4E5C-B3D7-D524DE5BAA94Q38544071-C2DA7ADA-2851-4302-B73A-C5AB05DC7B38Q38684521-E4EBBEB4-CBE0-4F1D-9DB7-1DA505D71FC2Q38960582-3BAA4748-1B3A-4374-8C8A-FED0D2BE375BQ39166511-8A5C32D6-5708-4BC7-A63C-D541EE151699Q39314599-D870162C-99C8-4CC7-9E15-88976F6F11BDQ39761680-F3F66CBF-82A9-42A1-8E6E-2C3AC025A18DQ40116179-3753A25A-CE73-4A0F-BBBF-78DA4CDD4A94Q41521830-A4418158-EA79-484D-B56A-0B238B2E0999Q42505249-2CD249B3-4B20-4F4F-B1B4-706A35613263Q42730547-0551C47E-23E7-41BF-81B0-03D837830599Q43414901-D881DA69-C636-45CD-9B94-9E5CF0C53F2CQ45923967-9C7AAA61-AB07-426E-B520-461DC776DF2DQ45992887-AD2E6B0C-3335-45ED-8441-17AB5EF0707EQ46091349-378E2A33-3A10-4655-8F78-4079505F4EADQ46405085-59747288-AA43-4456-A0B8-0EBF84948755Q46663722-3C684C9B-04D6-4519-A54B-6638BC556A9A
P2860
Human hepatocytes: isolation, cryopreservation and applications in drug development.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Human hepatocytes: isolation, cryopreservation and applications in drug development.
@ast
Human hepatocytes: isolation, cryopreservation and applications in drug development.
@en
Human hepatocytes: isolation, cryopreservation and applications in drug development.
@nl
type
label
Human hepatocytes: isolation, cryopreservation and applications in drug development.
@ast
Human hepatocytes: isolation, cryopreservation and applications in drug development.
@en
Human hepatocytes: isolation, cryopreservation and applications in drug development.
@nl
prefLabel
Human hepatocytes: isolation, cryopreservation and applications in drug development.
@ast
Human hepatocytes: isolation, cryopreservation and applications in drug development.
@en
Human hepatocytes: isolation, cryopreservation and applications in drug development.
@nl
P1476
Human hepatocytes: isolation, cryopreservation and applications in drug development.
@en
P356
10.1016/J.CBI.2007.01.001
P50
P577
2007-01-09T00:00:00Z