Increased functional stability and homogeneity of viral envelope spikes through directed evolution.
about
HIV-1 neutralizing antibodies: understanding nature's pathwaysA saposin-lipoprotein nanoparticle system for membrane proteins.Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing EpitopesA next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodiesInduction of a Tier-1-like Phenotype in Diverse Tier-2 Isolates by Agents that Guide HIV-1 Env to Perturbation-sensitive, Non-native States.HIV Envelope gp120 Alters T Cell Receptor Mobilization in the Immunological Synapse of Uninfected CD4 T Cells and Augments T Cell ActivationAntibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralizationStapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies.Directed evolution of a yeast-displayed HIV-1 SOSIP gp140 spike protein toward improved expression and affinity for conformational antibodies.Immunogenic Display of Purified Chemically Cross-Linked HIV-1 Spikes.Phenotypic Correlates of HIV-1 Macrophage Tropism.Molecular determinants of the ratio of inert to infectious virus particles.A functional interaction between gp41 and gp120 is observed for monomeric but not oligomeric, uncleaved HIV-1 Env gp140.Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein.Dense Array of Spikes on HIV-1 Virion Particles.HIV-1 Escape from a Peptidic Anchor Inhibitor through Stabilization of the Envelope Glycoprotein SpikeInfluences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers.Functional Stability of HIV-1 Envelope Trimer Affects Accessibility to Broadly Neutralizing Antibodies at its Apex.Topological analysis of HIV-1 glycoproteins expressed in situ on virus surfaces reveals tighter packing but greater conformational flexibility than for soluble gp120.FUNCTIONAL OPTIMIZATION OF BROADLY NEUTRALIZING HIV-1 ANTIBODY 10E8 BY PROMOTING MEMBRANE INTERACTIONS.Ocular delivery of proteins and peptides: challenges and novel formulation approaches.A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers.Stabilizing HIV-1 envelope glycoprotein trimers to induce neutralizing antibodies
P2860
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P2860
Increased functional stability and homogeneity of viral envelope spikes through directed evolution.
description
2013 nî lūn-bûn
@nan
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Increased functional stability ...... es through directed evolution.
@ast
Increased functional stability ...... es through directed evolution.
@en
Increased functional stability ...... es through directed evolution.
@nl
type
label
Increased functional stability ...... es through directed evolution.
@ast
Increased functional stability ...... es through directed evolution.
@en
Increased functional stability ...... es through directed evolution.
@nl
prefLabel
Increased functional stability ...... es through directed evolution.
@ast
Increased functional stability ...... es through directed evolution.
@en
Increased functional stability ...... es through directed evolution.
@nl
P2860
P1433
P1476
Increased functional stability ...... es through directed evolution.
@en
P2093
Daniel P Leaman
Michael B Zwick
P2860
P304
P356
10.1371/JOURNAL.PPAT.1003184
P577
2013-02-28T00:00:00Z