Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations - Wikidata - wikimedia - TriplyDB

Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations

Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations

http://www.wikidata.org/entity/Q34611774

about

Loss-of-function mutations in PTPN11 cause metachondromatosis, but not Ollier disease or Maffucci syndrome.Protein tyrosine phosphatases ε and α perform nonredundant roles in osteoclasts.SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates SHP2 regulates osteoclastogenesis by promoting preosteoclast fusion.FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling.LST1/A is a myeloid leukocyte-specific transmembrane adaptor protein recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to the plasma membrane.TLT-1s, alternative transcripts of triggering receptor expressed on myeloid cell-like transcript-1 (TLT-1), Inhibits the triggering receptor expressed on myeloid cell-2 (TREM-2)-mediated signaling pathway during osteoclastogenesis Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice.Induction of SHP2 deficiency in chondrocytes causes severe scoliosis and kyphosis in mice.Distinct and overlapping functions of ptpn11 genes in Zebrafish development.Protein tyrosine phosphatases in health and disease.Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention.Modeling RASopathies with Genetically Modified Mouse Models.Targeted disruption of Shp2 in chondrocytes leads to metachondromatosis with multiple cartilaginous protrusions Production of Osteoclasts for Studying Protein Tyrosine Phosphatase Signaling.Identification of novel genetic loci for osteoporosis and/or rheumatoid arthritis using cFDR approach.Ptpn11 Deletion in CD4+ Cells Does Not Affect T Cell Development and Functions but Causes Cartilage Tumors in a T Cell-Independent Manner.SHP2-Deficiency in Chondrocytes Deforms Orofacial Cartilage and Ciliogenesis in Mice.The use of SHP-2 gene transduced bone marrow mesenchymal stem cells to promote osteogenic differentiation and bone defect repair in rat.

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Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations

http://www.wikidata.org/entity/Q34611774

description

2010 nî lūn-bûn

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2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Development of severe skeletal ...... in humans with SHP-2 mutations

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Development of severe skeletal ...... in humans with SHP-2 mutations

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Development of severe skeletal ...... in humans with SHP-2 mutations

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Development of severe skeletal ...... in humans with SHP-2 mutations

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Development of severe skeletal ...... in humans with SHP-2 mutations

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Development of severe skeletal ...... in humans with SHP-2 mutations

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Development of severe skeletal ...... in humans with SHP-2 mutations

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Development of severe skeletal ...... in humans with SHP-2 mutations

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Development of severe skeletal ...... in humans with SHP-2 mutations

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Disease Models & Mechanisms

P1476

Development of severe skeletal ...... in humans with SHP-2 mutations

@en

P2093

Eric Langewisch

http://www.w3.org/2001/XMLSchema#string

Gen-Sheng Feng

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John E Wilkinson

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Nobuhiro Kamiya

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Philip D King

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Philip E Lapinski

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Yuji Mishina

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P2860

Leopard syndrome

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene

Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1

Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease.

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

Multiple lentigenes syndrome

Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss

Shp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiation

PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects

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228-239

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scholarly article

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10.1242/DMM.006130

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2

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4

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Timothy J Bauler

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2010-11-10T00:00:00Z

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47742684

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21068439

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3046097

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