FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling.
about
The emerging role of FTY720 (Fingolimod) in cancer treatmentSphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progressPAK1 is a novel cardiac protective signaling moleculeFTY720 protects cardiac microvessels of diabetes: a critical role of S1P1/3 in diabetic heart diseasePak1 as a novel therapeutic target for antihypertrophic treatment in the heartCardiac Safety Profile of First Dose of Fingolimod for Relapsing-Remitting Multiple Sclerosis in Real-World Settings: Data from a German Prospective Multi-Center Observational Study.The differential effects of FTY720 on functional recovery and infarct size following myocardial ischaemia/reperfusion.The outbreak fingolimod cardiovascular side effects in relapsing-remitting multiple sclerosis patient: A longitudinal study in an Iranian population.Novel bradykinin signaling in adult rat cardiac myocytes through activation of p21-activated kinase.The curious role of sarcomeric proteins in control of diverse processes in cardiac myocytes.P21-activated kinase in inflammatory and cardiovascular disease.Pharmacological pre- and post-conditioning with the sphingosine-1-phosphate receptor modulator FTY720 after myocardial ischaemia-reperfusionCardiovascular effects of fingolimod: A review article.Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system.S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes.Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury.The effect of the sphingosine-1-phosphate analogue FTY720 on atrioventricular nodal tissue.p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylationThe immunosuppressant FTY720 prolongs survival in a mouse model of diet-induced coronary atherosclerosis and myocardial infarction.Knockout of p21-activated kinase-1 attenuates exercise-induced cardiac remodelling through altered calcineurin signallingNovel roles of PAK1 in the heart.FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning.Implication of sphingosin-1-phosphate in cardiovascular regulation.Serum sphingolipids level as a novel potential marker for early detection of human myocardial ischaemic injury.Unique catalytic activities and scaffolding of p21 activated kinase-1 in cardiovascular signalingCardioprotection in ischemia/reperfusion injury: spotlight on sphingosine-1-phosphate and bradykinin signalling.The potential role of sphingolipid-mediated cell signaling in the interaction between hyperglycemia, acute myocardial infarction and heart failure.A therapeutic approach to hyperglycaemia in the setting of acute myocardial infarction: spotlight on glucagon-like peptide 1.Role of p21-activated kinases in cardiovascular development and function.Activation of sphingosine-1-phosphate signalling as a potential underlying mechanism of the pleiotropic effects of statin therapy.Regulation of Ca(2+) transient by PP2A in normal and failing heart.Regulation of sarcoplasmic reticulum Ca2+ release by serine-threonine phosphatases in the heart.Roles and regulation of protein phosphatase 2A (PP2A) in the heart.A novel liposomal formulation of FTY720 (fingolimod) for promising enhanced targeted delivery.Depletion of PAK1 enhances ubiquitin-mediated survivin degradation in pancreatic β-cells.The p21-activated kinase 1 (Pak1) signalling pathway in cardiac disease: from mechanistic study to therapeutic exploration.PAK1 limits the expression of the pro-apoptotic protein Bad in pancreatic islet β-cells.Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System.Effect of sphingosine-1-phosphate on L-type calcium current and Ca(2+) transient in rat ventricular myocytes.Sphingosine 1-phosphate as a therapeutic target in heart failure: more questions than answers.
P2860
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P2860
FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
FTY720 prevents ischemia/reper ...... ivation of Pak1/Akt signaling.
@ast
FTY720 prevents ischemia/reper ...... ivation of Pak1/Akt signaling.
@en
FTY720 prevents ischemia/reper ...... ivation of Pak1/Akt signaling.
@nl
type
label
FTY720 prevents ischemia/reper ...... ivation of Pak1/Akt signaling.
@ast
FTY720 prevents ischemia/reper ...... ivation of Pak1/Akt signaling.
@en
FTY720 prevents ischemia/reper ...... ivation of Pak1/Akt signaling.
@nl
prefLabel
FTY720 prevents ischemia/reper ...... ivation of Pak1/Akt signaling.
@ast
FTY720 prevents ischemia/reper ...... ivation of Pak1/Akt signaling.
@en
FTY720 prevents ischemia/reper ...... ivation of Pak1/Akt signaling.
@nl
P2093
P2860
P1476
FTY720 prevents ischemia/reper ...... tivation of Pak1/Akt signaling
@en
P2093
Elizabeth Cartwright
Hanny Musa
R John Solaro
Tamer M A Mohamed
P2860
P304
P356
10.1016/J.YJMCC.2009.10.009
P577
2009-10-21T00:00:00Z