Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF - Wikidata - wikimedia - TriplyDB

Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF

Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF

http://www.wikidata.org/entity/Q34616462

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Identification of Critical Residues in G 13 for Stimulation of p115RhoGEF Activity and the Structure of the G 13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex Insights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF.Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica Structure of the Rho-specific guanine nucleotide-exchange factor Xpln Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2 The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex Tyrosine phosphorylation of Dbl regulates GTPase signaling Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity.Intramolecular interactions between the Dbl homology (DH) domain and the carboxyl-terminal region of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) act as an autoinhibitory mechanism for the regulation of MyoGEF functions.Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insights Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13 Acute activation of β2-adrenergic receptor regulates focal adhesions through βArrestin2- and p115RhoGEF protein-mediated activation of RhoA.Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins.Essential role of the NH2-terminal region of Cdc24 guanine nucleotide exchange factor in its initial polarized localization in Saccharomyces cerevisiae.Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase.

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Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF

http://www.wikidata.org/entity/Q34616462

description

2011 nî lūn-bûn

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Modulation of a GEF switch: au ...... change activity of p115-RhoGEF

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Modulation of a GEF switch: au ...... change activity of p115-RhoGEF

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Modulation of a GEF switch: au ...... change activity of p115-RhoGEF

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Modulation of a GEF switch: au ...... change activity of p115-RhoGEF

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Modulation of a GEF switch: au ...... change activity of p115-RhoGEF

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Modulation of a GEF switch: au ...... change activity of p115-RhoGEF

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Modulation of a GEF switch: au ...... change activity of p115-RhoGEF

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Modulation of a GEF switch: au ...... change activity of p115-RhoGEF

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Modulation of a GEF switch: au ...... change activity of p115-RhoGEF

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Protein Science

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Modulation of a GEF switch: au ...... change activity of p115-RhoGEF

@en

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Liang Guo

http://www.w3.org/2001/XMLSchema#string

Paul C Sternweis

http://www.w3.org/2001/XMLSchema#string

Stephen R Sprang

http://www.w3.org/2001/XMLSchema#string

Zhe Chen

http://www.w3.org/2001/XMLSchema#string

P2860

Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF

The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle

The Protein Data Bank

The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG

Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing

Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.

Multiple sequence alignment with the Clustal series of programs

PROCHECK: a program to check the stereochemical quality of protein structures

Processing of X-ray diffraction data collected in oscillation mode

Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

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107-117

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scholarly article

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10.1002/PRO.542

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1

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20

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2011-01-01T00:00:00Z

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21064165

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