Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
about
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) familyMicrovesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activityADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural OverviewDecorin: A Growth Factor Antagonist for Tumor Growth InhibitionExpression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degenerationADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formationBiosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15: a novel versican-cleaving proteoglycanaseDevelopment of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1.The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity.Matrix assisted laser desorption ionization mass spectrometry imaging identifies markers of ageing and osteoarthritic cartilage.Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis.Metabolism of cartilage proteoglycans in health and diseaseADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis.Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5Sulfated glycosaminoglycans control the extracellular trafficking and the activity of the metalloprotease inhibitor TIMP-3.Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implicationsCCN1 (Cyr61) Is Overexpressed in Human Osteoarthritic Cartilage and Inhibits ADAMTS-4 (Aggrecanase 1) Activity.MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein.Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma.Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes.Extracellular proteases as targets for drug developmentEvidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors.Effects of the mycotoxin nivalenol on bovine articular chondrocyte metabolism in vitro.Proteases involved in cartilage matrix degradation in osteoarthritis.Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilageAntibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification.Piperine mediates LPS induced inflammatory and catabolic effects in rat intervertebral disc.Novel role of ADAMTS-5 protein in proteoglycan turnover and lipoprotein retention in atherosclerosis.Dual regulation of metalloproteinase expression in chondrocytes by Wnt-1-inducible signaling pathway protein 3/CCN6.Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex.Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases.Modulatory effects of proteoglycans on proteinase activities.Single Nucleotide Variants of Candidate Genes in Aggrecan Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes.Cartilage stem/progenitor cells are activated in osteoarthritis via interleukin-1β/nerve growth factor signalingPromotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect.The postnatal role of Sox9 in cartilage.Effects of cleavage by a disintegrin and metalloproteinase with thrombospondin motifs-4 on gene expression and protein content of versican and aggrecan in the digital laminae of horses with starch gruel-induced laminitis.Distribution and processing of a disintegrin and metalloproteinase with thrombospondin motifs-4, aggrecan, versican, and hyaluronan in equine digital laminae.
P2860
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P2860
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
@ast
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
@en
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
@nl
type
label
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
@ast
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
@en
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
@nl
prefLabel
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
@ast
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
@en
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
@nl
P2093
P50
P356
P1476
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
@en
P2093
Christi Gendron
Hideaki Nagase
Ida B Thøgersen
Masahide Kashiwagi
P304
18294-18306
P356
10.1074/JBC.M701523200
P407
P577
2007-04-12T00:00:00Z